04665nam 2200925Ia 450 991096010500332120251017110121.09780309168595030916859797803095044090309504406(CKB)111069351131834(SSID)ssj0000099317(PQKBManifestationID)11113484(PQKBTitleCode)TC0000099317(PQKBWorkID)10006838(PQKB)10407788(MiAaPQ)EBC3375425(Au-PeEL)EBL3375425(CaPaEBR)ebr10038699(OCoLC)923256358(Perlego)4732987(DNLM)1177101(BIP)53858393(BIP)8855966(EXLCZ)9911106935113183420030617d2003 uy 0engurcn|||||||||txtccrAdvancing prion science guidance for the National Prion Research Program, interim report /Rick Erdtmann and Laura Sivitz, editors ; Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science, Medical Follow-Up Agency, Institute of Medicine of the National Academies1st ed.Washington, D.C. The National Academies Press2003xx, 105 pBibliographic Level Mode of Issuance: Monograph9780309087445 0309087449 Includes bibliographical references.Front Matter -- Reviewers -- Preface -- Acknowledgments -- Contents -- Figures, Tables, and Boxes -- Abbreviations and Acronyms -- Executive Summary -- 1 Introduction -- 2 Prion Diseases and Their Challenges -- 3 Diagnostics for Transmissible Spongiform Encephalopathies -- 4 Research Recommendations for TSE Diagnostics -- 5 Prion Research Infrastructure -- 6 Risks to the U.S. Military -- Appendix Study Methods.In Advancing Prion Science, the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs' from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment. This report summarizes the progress thus far.Prion diseasesResearchUnited StatesPrion diseasesDiagnosisUnited StatesMedicine, MilitaryPublic healthUnited StatesSlow virus diseasesPreventionCreutzfeldt-Jakob diseasePreventionBovine spongiform encephalopathyPrion Diseasesprevention & controlPublic HealthPrion DiseasesdiagnosisMilitary MedicinePublic PolicyHealth PolicyUnited StatesPrion diseasesResearchPrion diseasesDiagnosisMedicine, Military.Public healthSlow virus diseasesPrevention.Creutzfeldt-Jakob diseasePrevention.Bovine spongiform encephalopathy.Prion Diseasesprevention & control.Public Health.Prion Diseasesdiagnosis.Military Medicine.Public Policy.Health Policy.616.8/3Erdtmann Rick1790846Sivitz Laura1790847Institute of Medicine (U.S.).Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science.MiAaPQMiAaPQMiAaPQBOOK9910960105003321Advancing prion science4327595UNINA