05136nam 2200925Ia 450 991096003150332120251017110057.0978030952781397866101767179781280176715128017671797803095278110309527813(CKB)111087027010014(OCoLC)70749613(CaPaEBR)ebrary10049206(SSID)ssj0000176892(PQKBManifestationID)11165721(PQKBTitleCode)TC0000176892(PQKBWorkID)10206485(PQKB)11347617(MiAaPQ)EBC3375900(Au-PeEL)EBL3375900(CaPaEBR)ebr10049206(CaONFJC)MIL17671(OCoLC)923259831(Perlego)4735258(DNLM)1207610(BIP)10324219(EXLCZ)9911108702701001420040218d2004 uy 0engurcn|||||||||txtccrImmunization safety review influenza vaccines and neurological complications /Immunization Safety Review Committee, Board on Health Promotion and Disease Prevention ; Kathleen Stratton ... [et al.], editors, Institute of Medicine of the National Academies1st ed.Washington, D.C. National Academies Pressc20041 online resource (190 p.)Bibliographic Level Mode of Issuance: MonographPrint version: Immunization safety review. Washington, D.C. : National Academies Press, ©2004 0309090865 (OCoLC)54444600 9780309090865 0309090865 Includes bibliographical references.FrontMatter -- Reviewers -- Foreword -- Acknowledgments -- Contents -- Executive Summary -- Immunization Safety Review: Influenza Vaccines and Neurological Complications -- THE CHARGE TO THE COMMITTEE -- THE STUDY PROCESS -- THE FRAMEWORK FOR SCIENTIFIC ASSESSMENT -- UNDER REVIEW: INFLUENZA VACCINES AND NEUROLOGICAL COMPLICATIONS -- SCIENTIFIC ASSESSMENT -- SIGNIFICANCE ASSESSMENT -- RECOMMENDATIONS FOR PUBLIC HEALTH RESPONSE -- SUMMARY -- REFERENCES -- Appendixes -- Appendix A Committee Recommendations and Conclusions from Previous Reports -- Appendix B Public Meeting Agenda March 13, 2003 -- Appendix C Chronology of Important Events Regarding Vaccine Safety -- Appendix D Acronyms.Infection with the influenza virus can have a serious effect on the health of people of all ages, although it is particularly worrisome for infants, the elderly, and people with underlying heart or lung problems. A vaccine exists (the oeflu shot) that can greatly decrease the impact of influenza. Because the strains of virus that are expected to cause serious illness and death are slightly different every year, the vaccine is also slightly different every year and it must be given every year, unlike other vaccines. The Immunization Safety Review committee reviewed the data on influenza vaccine and neurological conditions and concluded that the evidence favored rejection of a causal relationship between influenza vaccines and exacerbation of multiple sclerosis. For the other neurological conditions studied, the committee concluded the evidence about the effects of influenza vaccine is inadequate to accept or reject a causal relationship. The committee also reviewed theories on how the influenza vaccine could damage the nervous system. The evidence was at most weak that the vaccine could act in humans in ways that could lead to these neurological problems.Influenza vaccinesSide effectsNervous systemDiseasesImmunological aspectsImmunizationComplicationsVaccinationComplicationsInfluenza Vaccinesadverse effects(DNLM)D007252Q000009Infant(DNLM)D007223Vaccinationadverse effects(DNLM)D014611Q000009Nervous System Diseasesetiology(DNLM)D009422Q000209Immunization Schedule(DNLM)D007115Immune System Diseasesetiology(DNLM)D007154Q000209Safety(DNLM)D012449United StatesInfluenza vaccinesSide effects.Nervous systemDiseasesImmunological aspects.ImmunizationComplications.VaccinationComplications.Influenza Vaccinesadverse effects.Infant.Vaccinationadverse effects.Nervous System Diseasesetiology.Immunization Schedule.Immune System Diseasesetiology.Safety.614.5/18Stratton Kathleen R1797964Institute of Medicine (U.S.).Immunization Safety Review Committee.MiAaPQMiAaPQMiAaPQBOOK9910960031503321Immunization safety review4356336UNINA