03184nam 2200601Ia 450 991095858300332120251116221328.01-60741-670-0(CKB)2560000000070922(EBL)3018523(SSID)ssj0000472797(PQKBManifestationID)11284032(PQKBTitleCode)TC0000472797(PQKBWorkID)10434725(PQKB)10722638(MiAaPQ)EBC3018523(BIP)25941637(EXLCZ)99256000000007092220090228d2009 uy 0engur|n|---|||||txtccrThe ribonucleotide reductase family genetics and genomics /Eduard Torrents, Margareta Sahlin and Britt-Marie Sjoberg1st ed.New York Nova Biomedical Booksc20091 online resource (109 p.)Novinka The ribonucleotide reductase familyDescription based upon print version of record.1-60692-419-2 Includes bibliographical references (p. [65]-87) and index.Intro -- THE RIBONUCLEOTIDEREDUCTASE FAMILY:GENETICS AND GENOMICS -- Contents -- Preface -- Introduction -- RNR Classification and Occurrence -- Class I RNRs -- Class II RNRs -- Class III RNRs -- RNR distribution as seen in RNRdb -Ribonucleotide Reductase Database -- Atypical and Unconventional RNRs -- RNR Diversification -- Modularity Hypothesis for RNR ClassDiversificatio -- Regulation of RNRs -- Archaea -- Eubacteria -- Mutational Studies in RNRs -- RNR as an Antiproliferative Targetfor Disease Control -- Substrate Analogues -- Radical Scavengers Attacking the TyrosylRadical -- Iron Chelators -- Peptidomimetics Corresponding to the CTerminusof NrdB -- Manipulating the Expression of RNR -- Other Potential Inhibitors and AllostericNucleotide Analogues -- Future Antiproliferative Regimes -- Acknowledgments -- References -- Index.Ribonucleotide reductase (RNR), has a central role in DNA replication and repair by catalysing production of deoxyribonucleotides from the corresponding ribonucleotides. The authors describe a comprehensive summary of how the expression of RNR genes is regulated in several eubacterial organisms and in yeast. Due to RNR's importance for the realisation of DNA replication, it has been recognised as a possible target for antiproliferative therapy. The authors present a comprehensive summary of RNR-specific inhibitors that have reached clinical trials and/or are currently used in clinical therapy.OxidoreductasesEnzymesGeneticsGenomicsOxidoreductases.Enzymes.Genetics.Genomics.572/.791Torrents Eduard1866849Sahlin Margareta1866850Sjoberg Britt-Marie1866851MiAaPQMiAaPQMiAaPQBOOK9910958583003321The ribonucleotide reductase family4474314UNINA