05365nam 2200661 a 450 991102017160332120200520144314.0978661103198597812810319831281031984978047051309504705130989780470513088047051308X(CKB)1000000000377301(EBL)316236(SSID)ssj0000123520(PQKBManifestationID)11143360(PQKBTitleCode)TC0000123520(PQKBWorkID)10014335(PQKB)10019298(MiAaPQ)EBC316236(OCoLC)184983232(Perlego)2754868(EXLCZ)99100000000037730120070416d2007 uy 0engur|n|---|||||txtccrClinical diabetes research methods and techniques /edited by Michael RodenChichester, West Sussex, England ;Hoboken, N.J. John Wiley and Sonsc20071 online resource (424 p.)Description based upon print version of record.9780470017289 0470017287 Includes bibliographical references and index.Clinical Diabetes Research; Contents; List of Contributors; 1 Basics of Clinical Metabolic Research; 2 Methods for the Assessment of β-Cell Function In Vivo; Introduction; Methods for insulin secretion in vivo; β-cell response characteristics; β-cell function tests; Modelling methods; β-cell function and insulin sensitivity; Comparative evaluation of methods; Conclusion; 3 Assessment of Insulin Sensitivity from Steady-State and Dynamic Tests; Introduction; Insulin sensitivity from steady-state tests; Insulin sensitivity from dynamic tests; Conclusion; 4 Glucose Clamp Techniques; IntroductionBasic principles of the euglycaemic hyperinsulinaemic clamp techniqueMethodology; Reproducibility of insulin sensitivity obtained from clamp tests; Safety considerations for hyperinsulinaemiac euglycaemic clamp test; Modifications of the euglycaemic hyperinsulinaemic clamp test protocol; Conclusion; 5 Methods of Assessment of Counterregulation to Hypoglycaemia; Introduction; Definitions; Pathophysiology; Documentation of hypoglycaemia experience; Investigating the pathogenesis of problematic hypoglycaemia; Hypoglycaemic stimuli for research; Measurement of physiological responses; Conclusion6 Glucose Kinetics: Measurement of Flux RatesIntroduction; Measurement of glucose production and uptake by the liver - tissue balance techniques; Properties of glucose tracers; Measurement of glucose production and uptake by the liver - systemic techniques; Conclusion; Acknowledgements; 7 Xenobiotics as Probes of Carbohydrate Metabolism; Introduction; Glucuronidation; Glutamination; Ribosylation; Acetylation; Glycination; 8 Tracing Hepatic Glucose and Glycogen Fluxes with 2H2O; Introduction; Methodology; Theoretical considerations; Quantifying hepatic glucose and glycogen metabolismConclusion9 Lipid Kinetics; Introduction; Tracers for the study of adipose tissue lipolysis; Tracers for the study of triglyceride-rich lipoprotein kinetics; Conclusion; Acknowledgements; 10 Protein and Amino Acid Kinetics; Introduction; Measuring amino acid turnover; Measuring protein turnover; Proteome dynamics; Urea kinetics; Determining the molecular control of protein dynamics; Conclusion; Acknowledgements; 11 Assessment of Metabolic Fluxes by In Vivo MR Spectroscopy; Phenomena of nuclear magnetic resonance - imaging and spectroscopy; Skeletal muscle; Liver; Brain; Conclusion12 Positron Emission Tomography in Metabolic ResearchIntroduction; Tracers for metabolic imaging; Principles of modeling; Future perspectives; 13 Assessment of Body Fat Content and Distribution; Introduction; Measurement techniques; Body fat distribution and insulin resistance; 14 Tissue Biopsies in Diabetes Research; Introduction; Percutaneous needle biopsy of skeletal muscle; Biopsy procedure and sample handling; Discomfort and complications of needle biopsy; Advantages and limitations of needle biopsy; Application of muscle biopsy in diabetes; Morphology of skeletal muscleApplication of muscle morphology in type 2 diabetesA practical ""how to"" guide for multiple methods in metabolism, with a critical and objective discussion of strengths, limitations, and appropriate applications of the described methods. Edited by the winner of the Oskar-Minkowski Prize of the EASD in 2006 Clinical trials in populations at risk of or with overt diabetes mellitus are being performed all around the world to test novel drugs and approaches to managing these diseases. During the last decade, new methods and techniques have been introduced - and are being developed further - that facilitate monitoring of metaboliDiabetesDiabetesResearchDiabetes.DiabetesResearch.616.4/620072Roden MichaelDr.1839385MiAaPQMiAaPQMiAaPQBOOK9911020171603321Clinical diabetes research4418596UNINA05050nam 22008893u 450 991095764240332120251116210413.01-136-88704-01-136-88705-91-283-04364-597866130436410-203-83978-1(CKB)2560000000049019(EBL)667848(OCoLC)711874860(SSID)ssj0000468866(PQKBManifestationID)12143143(PQKBTitleCode)TC0000468866(PQKBWorkID)10508200(PQKB)10870823(MiAaPQ)EBC667848(EXLCZ)99256000000004901920130418d2010|||| u|| |engur|n|---|||||txtccrEquality, Participation and Inclusion 1 Diverse Perspectives2nd ed.Hoboken Taylor and Francis20101 online resource (350 p.)Description based upon print version of record.0-415-58423-X Book Cover; Title; Copyright; Contents; Acknowledgements; Chapter 1 Introduction: Another point of view; Chapter 2 Mabel Cooper's life story; Chapter 3 'The stairs didn't go anywhere!': A self-advocate's reflections on specialised services and their impact on people with disabilities; Chapter 4 'Race', gender and educational desire; Chapter 5 Brushed behind the bike shed: Working-class lesbians' experiences of school; Chapter 6 Has classroom teaching served its day?; Chapter 7 The politics of education for all; Chapter 8 Why it remains important to take children's rights seriouslyChapter 9 Youth participation in the UK: Bureaucratic disaster or triumph of child rights?Chapter 10 Social model or unsociable muddle?; Chapter 11 Including all of our lives: Renewing the social model of disability; Chapter 12 Children's experiences of disability: Pointers to a social model of childhood disability; Chapter 13 Towards an affirmation model of disability; Chapter 14 The news of inclusive education: A narrative analysis; Chapter 15 Guardians of tradition: Presentations of inclusion in three introductory special education textbooksChapter 16 Transcending transculturalism?: Race, ethnicity and health-careChapter 17 Countering the Attention Deficit Hyperactivity Disorder epidemic: A question of ethics?; Chapter 18 Inclusion in mainstream classrooms: Experiences of deaf pupils; Chapter 19 Voices on: Teachers and teaching assistants talk about inclusion; Chapter 20 Lessons from the 1 per cent: Children with labels of severe disabilities and their peers as architects of inclusive education; Chapter 21 Children's 'social capital': Implications for health and well-beingChapter 22 Taking looked after children's views into account on a day-to-day level: The perceptions and experiences of children and social workersChapter 23 Aversive disablism: Subtle prejudice toward disabled people; Chapter 24 A collective model of difference; IndexWhat are the experiences of children and young people?How can we think about the challenges they face?What systems and practices can support them?How can we develop greater equality, participation and inclusion across diverse settings?This second edition of Equality, Participation and Inclusion 1: Diverse Perspectives is the first of two Readers aimed at people with an interest in issues of equality, participation and inclusion for children and young people. This first Reader focuses in particular on the diverse perspectives held by difInclusive educationInclusive educationMulticultural educationMulticultural educationSpecial educationSpecial educationInclusive educationGreat BritainSpecial educationGreat BritainMulticultural educationGreat BritainEducationHILCCSocial SciencesHILCCEducation, Special TopicsHILCCInclusive education.Inclusive education.Multicultural education.Multicultural education.Special education.Special education.Inclusive educationSpecial educationMulticultural educationEducationSocial SciencesEducation, Special Topics370.115371.9/046Rix Jon1863784Nind Melanie802814Sheehy Kieron944685Simmons Katy(Writer on Russian literature)1863785Walsh Christopher514842AU-PeELAU-PeELAU-PeELBOOK9910957642403321Equality, Participation and Inclusion 14470469UNINA