04269nam 2200673Ia 450 991095385040332120240417001332.09786610214747978128021474512802147409780309568142030956814597805851439100585143919(CKB)111004366658452(OCoLC)726823183(CaPaEBR)ebrary10071414(MiAaPQ)EBC3377387(Au-PeEL)EBL3377387(CaPaEBR)ebr10071414(CaONFJC)MIL21474(OCoLC)923270222(NjHacI)99111004366658452(BIP)000162739(Perlego)4735182(EXLCZ)9911100436665845219901022d1989 uy 0engurcn|||||||||txtrdacontentcrdamediacrrdacarrierBiologic markers in reproductive toxicology /Subcommittee on Reproductive and Neurodevelopmental Toxicology, Committee on Biologic Markers, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council1st ed.Washington, D.C. :National Academy Press,1989.1 online resource (xxi, 395 pages) illustrationsIncludes index.9780309039796 0309039797 Includes bibliography (p. 319-372) and index.Executive summary -- Report of the Oversight Committee. I. Biologic markers in male reproductive and gametic genetic toxicology. Introduction -- Clinical evaluation of male infertility -- Biologic markers of testicular function -- Biologic markers of epididymal structure and function -- Biologic markers of accessory sex organ structure and function -- Biologic markers of human male reproductive health and physiologic damage -- Assessing transmitted mutations in mice -- Markers for measuring germinal genetic toxicity and heritable mutations in people -- Conclusions and recommendations. II. Biologic markers in female reproductive toxicology. Introduction -- Biologic markers of genetic damage in females -- Biologic markers of reproductive development and aging -- Biologic markers of nonconceptive menstrual cycles -- Developing assays of biologic markers for epidemiologic studies: experience with a marker of pregnancy and early loss -- Conclusions and recommendations. III. Biologic markers of toxicity during pregnancy. Introduction -- Molecular biology: developing DNA markers of genotoxic effects -- Reproductive immunology: biologic markers of compromised pregnancies -- Cell biology: identifying biologic markers expressed during early pregnancy -- Physiologic assessment of fetal compromise -- Conclusions and Recommendations. IV. Biologic Markers in Neurodevelopmental Toxicology. Introduction -- Developmental neurobiology of the central nervous system -- Morphologic, neurochemical, and behavioral responses to toxic agents -- Methodologic issues of extrapolation from animal studies to human toxicant exposure -- Lead as a paradigm for the study of neurodevelopmental toxicology -- Conclusions and recommendations -- Appendix: Assessing the validity of biologic markers: alpha-fetoprotein -- References -- Biographies -- Index.Examines the potential use of these markers in environmental health studies, and clarifies definitions, underlying concepts, and possible applications. Acidic paper. Annotation(c) 2003 Book News, Inc., Portland, OR (booknews.com).Reproductive toxicologyBiochemical markersReproductive toxicology.Biochemical markers.616.6/507Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Biologic Markers,Subcommittee on Reproductive and Neurodevelopmental Toxicology,MiAaPQMiAaPQMiAaPQBOOK9910953850403321Biologic markers in reproductive toxicology4360325UNINA