04379nam 22006615 450 991091980950332120241225115243.09783031659379(electronic bk.)978303165936210.1007/978-3-031-65937-9(MiAaPQ)EBC31859390(Au-PeEL)EBL31859390(CKB)37081493800041(DE-He213)978-3-031-65937-9(EXLCZ)993708149380004120241225d2024 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierBiostatistics in Biopharmaceutical Research and Development Clinical Trial Analysis, Volume 2 /edited by Ding-Geng Chen1st ed. 2024.Cham :Springer Nature Switzerland :Imprint: Springer,2024.1 online resource (522 pages)Print version: Chen, Ding-Geng Biostatistics in Biopharmaceutical Research and Development Cham : Springer,c2025 9783031659362 Statistical Challenges in the Analysis of Biomarker Data -- 2. Evaluating Predictive Accuracy of Prognostic Model for Censored Time-to-Event Data Analysis in Clinical Trials -- Statistical Methods for Accommodating Immortal Time: A Selective Review and Comparison -- Variable selection for partially functional additive Cox Model with interval-censored failure time data -- A Bayesian proportional hazards model to predict patient recruitment in multicenter clinical trials -- GET MORE INFORMATION FROM RECURRENT EVENTS DATA -- Introduction to Patient Preference Studies -- Machine Learning for Precision Medicine and Humanized AI for Future Healthcare -- The Statistical Evaluation of Surrogate Endpoints in Clinical Trials -- Treatment Effect Estimation Using Data from Observational and Non-Randomized Studies -- Methods for Comparing Two Treatments for a Dichotomous Outcome for a Two-Period Design with Treatment Switching of Control Group Period 1 Non-Responders -- Regression-based estimation of optimal adaptive treatment strategies: Key methods -- Vaccine Disease-Prevention Efficacy Studies: Traditional Approaches and New Frontiers -- Covariate Adjustment in Analyzing Randomized Clinical Trials: Approaches, Software, and Application -- Joint correlated responses and feedback effect with time-dependent covariates -- Distributions and Their Approximations for P-Values.The Deming Conference on Applied Statistics has long been deemed an influential event in the biostatistics and biopharmaceutical profession. It provides learning experience on recent developments in statistical methodologies in biopharmaceutical applications and FDA regulations. This book honors 80 years of contributions and dedication of the Deming Conference in biostatistics, and biopharmaceutical clinical trial methodology and applications. All chapters are contributed by world-class and prominent Deming speakers, who've contributed their cutting-edge research and developments to the community. Volume 2 covers Biomarkers in Drug Development, Time-To-Event Data Analysis and Methods, and emerging development in biopharmaceutical biostatistics. This book aims to booster research, education, and training in biostatistics and in biopharmaceutical research and development. .StatisticsBiometryClinical medicineResearchSampling (Statistics)Public healthStatisticsBiostatisticsClinical ResearchMethodology of Data Collection and ProcessingSurvey MethodologyPublic HealthStatistics.Biometry.Clinical medicineResearch.Sampling (Statistics).Public health.Statistics.Biostatistics.Clinical Research.Methodology of Data Collection and Processing.Survey Methodology.Public Health.519.5Chen Ding-Geng767993MiAaPQMiAaPQMiAaPQ9910919809503321Biostatistics in Biopharmaceutical Research and Development4306295UNINA03659oam 22005774a 450 991052467870332120230621135921.00-8018-2864-31-4214-3058-4(CKB)4100000010460800(OCoLC)1120077210(MdBmJHUP)muse78125(oapen)https://directory.doabooks.org/handle/20.500.12854/88834(MiAaPQ)EBC29139174(Au-PeEL)EBL29139174(oapen)doab88834(OCoLC)1526862789(EXLCZ)99410000001046080020190913d2019 uy 0engur|||||||nn|ntxtrdacontentcrdamediacrrdacarrierThe Beginnings of National PoliticsAn Interpretive History of the Continental Congress /Jack N. RakoveOpen access edition.Johns Hopkins University Press2019Baltimore, Maryland :Project Muse,2019©20191 online resource (1 PDF (unpaged).)Hopkins open publishing encore editionsOriginally published: Baltimore, Maryland : Johns Hopkins University Press, 1982.1-4214-3098-3 1-4214-3013-4 Includes bibliographical references and index.part 1. Resistance and revolution : resistance without union, 1770-1774 -- The creation of a mandate -- The First Continental Congress -- War and politics, 1775-1776 -- Independence -- A lengthening war -- part 2. Confederation : confederation considered -- Confederation drafted -- The beginnings of national government -- Ambition and responsibility : an essay on revolutionary politics -- part 3. Crises : factional conflict and foreign policy -- A government without money -- The administration of Robert Morris -- part 4. Reform : union without power : the confederation in peacetime -- Toward the Philadelphia Convention.Despite a necessary preoccupation with the Revolutionary struggle, America's Continental Congress succeeded in establishing itself as a governing body with national--and international--authority. How the Congress acquired and maintained this power and how the delegates sought to resolve the complex theoretical problems that arose in forming a federal government are the issues confronted in Jack N. Rakove's searching reappraisal of Revolution-era politics. Avoiding the tendency to interpret the decisions of the Congress in terms of competing factions or conflicting ideologies, Rakove opts for a more pragmatic view. He reconstructs the political climate of the Revolutionary period, mapping out both the immediate problems confronting the Congress and the available alternatives as perceived by the delegates. He recreates a landscape littered with unfamiliar issues, intractable problems, unattractive choices, and partial solutions, all of which influenced congressional decisions on matters as prosaic as military logistics or as abstract as the definition of federalism.Hopkins open publishing encore editions.History of the AmericasbicsscUnited StatesPolitics and government1783-1789United StatesPolitics and government1775-1783Electronic books. History of the AmericasHistory of the AmericasRakove Jack N.1947-1088368MdBmJHUPMdBmJHUPBOOK9910524678703321The Beginnings of National Politics2605800UNINA