05722nam 22004813 450 991091579380332120230930060233.097819230421621923042165(MiAaPQ)EBC30757314(Au-PeEL)EBL30757314(CKB)28328640700041(Exl-AI)30757314(EXLCZ)992832864070004120230930d2023 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierAdventures in Gut Neuroscience1st ed.Adelaide :Wakefield Press Pty, Limited,2023.©2023.1 online resource (226 pages)9781923042124 1923042122 Cover -- Title page -- Imprint -- Dedication -- Contents page 1 -- Contents page 2 -- Foreword -- Introduction -- I. An adventurous and curious boy -- II. A New world -- III. Return to birthplace -- IV. The enteric plexuses in the 1960s -- V. Histochemistry of biogenic amines and the gut -- VI. First encounter with organ bath pharmacology -- VII. A political student and life in the 1960s -- VIII. Geoff Burnstock and the Australian adventure -- IX. Overcoming the tyranny of language in Melbourne in the '70s -- X. Cutting ties with Torino -- XI. European interlude via South America seeking a research career -- XII. Settling in Australia: from Melbourne to Adelaide -- XIII. Exploring the neural bases of intestinal behaviour -- Recording from enteric nuerons -- Polarity of enteric nerve pathways -- XIV. On the function of the enteric inhibitory motor neurons -- Developing new methods for visualizing adrenergic transmitters -- Beyond noradrenergic nerves: other amine neurons in the gut? -- XV. In search for more unknown transmitters in the gut: 5-hydroxytryptamine -- XVI. The environment at Flinders in mid 1970s -- XVII. On the conceptual distinction between the pharmacology and the physiology of neurotransmitters -- The era of neuropeptides in the nervous system -- XVIII. Whole-mount methods for visualizing neuropeptides in the intestine -- XIX. Substance P as an enteric neurotransmitter -- XX. The golden decade of the 1980s: unravelling the enteric circuits -- My links with a remarkable colleague -- XXI. Fast (spark) and slow (soup) synaptic transmission in the nervous system -- Slow synaptic transmission in the enteric nervous system -- XXII. VIP and the NANC inhibitory nerves -- One or more transmitters for every neuron -- Multiple neuronal markers -- XXIII. Visualising cholinergic neurons in the enteric nervous system (ENS).Where are te enteric motor neurons in gut? -- XXIV. Emergence of the concept of chemical coding of neurons -- Plurichemical transmission -- XXV. Multidisciplinary approach to unravelling enteric neural circuits -- Ultrastructure of the ENS and synaptic connections -- Analytical methods to confirm the biochemical nature of substances visualised by IHC. -- XXVI. Beyond the gut -- Other species -- Travelling as a researcher to Japan -- XXVII. Was our work on guinea pigs wasted? -- Beyond the gut again -- XXVIII. The 1990s -- a decade of closures and further explorations -- The gut and opioid drugs -- The discovery of nitric oxide as neurotransmitter -- Using the chemical coding concept to identify more functional classes of enteric neurons -- Neurofilaments in enteric neurons -- XXIX.F inal unravelling of the enteric circuits -- the arrival of Simon Brookes -- XXX. Spatial pharmacology -- Mechanisms of peristalsis in the isolated guinea-pig small intestine -- The first comprehensive summary of the identifiable classes of enteric neurons -- XXXI. Presidency of the Australian Neuroscience Society and other adventures -- Further adventures in Patagonia -- Crossing waters by sailboard -- Working with a giant pharmaceutical company: AstraZeneca -- My links with Swedish scientists -- XXXII. The Human ENS -- Extending studies to the innervation of other viscera -- XXXIII. Teaching administration and research -- Varenna teaching slides -- Cognitive science course at Flinders -- XXXIV.The new millennium -- beyond anatomy and physiology -- spatio-temporal representation of gut movements -- Modelling of peristalsis -- XXXV. Back to the brain and eventually back to the gut -- Return to the experimental labs -- Developing the new spatio-temporal mapping methods -- XXXVI. My last years: the enteric circuits in the modern era.Conceptual issues remaining open at the end of my research career -- Acknowledgements -- References -- Brief Curriculum Vitae -- Chronology -- Research productivity -- Conferences -- Teaching -- Public Engagement -- Colleagues perspectives -- John Chalmers, AC FAA FAAHMS FRACP -- John Furness FAA -- Bill Blessing -- Ian Gibbins -- Judy Morris -- Simon Brookes -- Nick Spencer -- Phil Dinning -- Wakefield Press -- Back cover.Marcello Costa published his first paper in Neuro-gastroenterology in 1965. He pioneered many methods to investigate the organization and functions of the so-called 'little brain in the gut', the Enteric Nervous System. This monograph summarizes his extensive work in collaboration with close to 200 colleagues from different countries.NeurosciencesGenerated by AIGastrointestinal systemGenerated by AINeurosciences.Gastrointestinal system.Costa Marcello511950MiAaPQMiAaPQMiAaPQBOOK9910915793803321Adventures in Gut Neuroscience4303351UNINA