00943nam a22002531i 450099100266722970753620040219141334.0040624s1997 it a||||||||||||||||ita b1295911x-39ule_instARCHE-091679ExLDip.to Beni CulturaliitaA.t.i. Arché s.c.r.l. Pandora Sicilia s.r.l.471.7Susini, Giancarlo204231Epigraphica dilapidata /scritti scelti di Giancarlo SusiniFaenza :Fratelli Lega,1997547 p. :ill. ;24 cmEpigrafia e antichità ;15Epigrafia latina.b1295911x02-04-1412-07-04991002667229707536LE001 AN III 10912001000049110le001C. 1-E0.00-l- 00000.i1356032312-07-04Epigraphica dilapidata280028UNISALENTOle00112-07-04ma -itait 0103512nam 22005175 450 991089653550332120241015125734.0981-9766-95-810.1007/978-981-97-6695-6(CKB)36357555400041(DE-He213)978-981-97-6695-6(EXLCZ)993635755540004120241015d2024 u| 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierCircadian Clock and Aging /by Syed Ibrahim Rizvi, Gaurav Majumdar1st ed. 2024.Singapore :Springer Nature Singapore :Imprint: Springer,2024.1 online resource (XII, 204 p. 25 illus., 24 illus. in color.) 981-9766-94-X 1. Introduction to Circadian Rhythms -- 2. Mechanisms of Circadian Oscillations -- 3. Light Sensitivity of the Biological Clock -- 4. Circadian System and Aging in Rodent Models -- 5. Circadian Control of Mitochondrial Dynamics and Its Implication in Aging -- 6. Health Consequences of Circadian Disruption in Humans and Animal Models during aging -- 7. The Human SCN in Health and Age-related Neurological Disorders -- 8. The Circadian Clock as a drug target for anti-aging strategies.This book aims to understand the inherent circadian cycles of biological processes and their role in maintaining health and healing a variety of diseases. The book is divided into eight sections. The first section introduces circadian rhythms and aging. The second section focuses on the detailed mechanistic approach of oscillatory pathways in mammals. The next section summarizes the sensitivity of the biological clock towards light and the circadian response to melatonin in mammals. The fourth section addresses the circadian architecture at the cellular level and introduces an age-dependent experimental model of rodents for subsequent biochemical and molecular investigations. The subsequent section covers the complexity of circadian regulation in mitochondrial dynamics and its impact on aging. The sixth section of the book discusses the findings obtained from different experimental approaches as a critical threat to the functioning of clock regulatory mechanisms and its associated health consequences during aging in humans and animal models. The circadian oscillatory mechanisms that are dysregulated and might play an important role in the development and progression of neurological disorders such as Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Huntington’s Disease (HD), and Amyotrophic Lateral Sclerosis (ALS), etc are discussed in the next section. Towards the end, the book explores the circadian clock as a possible drug target to restore circadian oscillations.AgingCytologyCircadian rhythmsDiseasesAgeingCellular Circadian RhythmsDiseasesAging.Cytology.Circadian rhythms.Diseases.Ageing.Cellular Circadian Rhythms.Diseases.571.878Rizvi Syed Ibrahimauthttp://id.loc.gov/vocabulary/relators/autMajumdar Gauravauthttp://id.loc.gov/vocabulary/relators/autBOOK9910896535503321Circadian Clock and Aging4223016UNINA