02713nam 22005175 450 991089653120332120241014125730.0981-9748-64-X10.1007/978-981-97-4864-8(MiAaPQ)EBC31727240(Au-PeEL)EBL31727240(CKB)36358591400041(DE-He213)978-981-97-4864-8(EXLCZ)993635859140004120241014d2024 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierChemistry and Biology of O-GlcNAcylation /edited by Wen Yi1st ed. 2024.Singapore :Springer Nature Singapore :Imprint: Springer,2024.1 online resource (178 pages)981-9748-63-1 Chapter 1. Chemical tools for decoding the functions of O-GlcNAcylation -- Chapter 2. Profiling O-GlcNAcylation with mass spectrometry -- Chapter 3. O-GlcNAcylation and cell metabolism -- Chapter 4. O-GlcNAcylation and transcriptional regulation and epigenetics -- Chapter 5. O-GlcNAcylation and signal transduction -- Chapter 6. O-GlcNAcylation and stem cells -- Chapter 7. O-GlcNAcylation and immune regulation -- Chapter 8. O-GlcNAcylation and neuronal development, neurodegeneration and neurological disorders.O-linked N-acetylglucosamine (O-GlcNAc) is a prevalent post-translational modification of numerous intracellular proteins. This modification has recently emerged as a key regulator of various important biological processes, including gene transcription, stress response, metabolic homeostasis, and immune regulation. Given the critical role of O-GlcNAc in normal physiology, increasing evidence has now demonstrated that deregulation of O-GlcNAc is closely associated with the development and progression of various diseases, including neurodegeneration, cardiovascular disease, and cancer. This book provides a comprehensive overview of the current progress and understanding of this modification in biology, and likely provides new research directions in the future.MedicineResearchBiologyResearchCytologyBiomedical ResearchCell BiologyMedicineResearch.BiologyResearch.Cytology.Biomedical Research.Cell Biology.572.68Yi Wen1766651MiAaPQMiAaPQMiAaPQBOOK9910896531203321Chemistry and Biology of O-GlcNAcylation4211318UNINA