01457nas 2200409-a 450 991089148910332120240413014750.02362-5635(CKB)2320000000014870(CONSER)--2009223120(DE-599)ZDB2675009-0(EXLCZ)99232000000001487020081007a20079999 --- -spaCuadernos de cine documentalSanta Fe, Argentina Ediciones UNL2007-1 online resourcePrint version: Cuadernos de cine documental. 1851-1627 (DLC) 2009223120 (OCoLC)277069334 Documentary filmsArgentinaHistory and criticismPeriodicalsDocumentary filmsHistory and criticismPeriodicalsMotion picturesArgentinaPeriodicalsDocumentary filmsfast(OCoLC)fst00896079Motion picturesfast(OCoLC)fst01027285ArgentinafastCriticism, interpretation, etc.fastPeriodicals.fastDocumentary filmsHistory and criticismDocumentary filmsHistory and criticismMotion picturesDocumentary films.Motion pictures.Universidad Nacional del Litoral.JOURNAL9910891489103321exl_impl conversionCuadernos de cine documental4256783UNINA05574nam 2200733Ia 450 991101935370332120200520144314.09786610519484978128051948212805194879783527603756352760375197835276038483527603840(CKB)1000000000376379(EBL)481511(OCoLC)69243366(SSID)ssj0000211433(PQKBManifestationID)11201930(PQKBTitleCode)TC0000211433(PQKBWorkID)10293010(PQKB)11149194(MiAaPQ)EBC481511(Perlego)2764740(EXLCZ)99100000000037637920040716d2005 uy 0engur|n|---|||||txtccrNitric oxide donors for pharmaceutical and biological applications /edited by Peng George Wang, Tingwei Bill Cai, Naoyuki TaniguchiWeinheim ;[Great Britain] Wiley-VCHc20051 online resource (414 p.)Description based upon print version of record.9783527310159 3527310150 Includes bibliographical references and index.Nitric Oxide Donors; Contents; Preface; List of Contributors; Part 1 Chemistry of NO Donors; 1 NO and NO Donors; 1.1 Introduction to NO Biosynthesis and NO donors; 1.1.1 Nitric Oxide Synthases; 1.1.2 Chemistry of Reactive Nitrogen Species; 1.2 Classification of NO Donors; 1.3 New Classes of NO Donors under Development; 1.3.1 Nitroarene; 1.3.2 Hydroxamic Acids; 1.4 Development of NO-Drug Hybrid Molecules; 1.4.1 Nitrate Hybrid Molecules; 1.4.2 Furoxan Hybrid Molecules; 1.5 New Therapeutic Applications of NO Donors; 1.5.1 NO Donors against Cancer1.5.1.1 Diazeniumdiolates (NONOates) as Promising Anticancer Drugs1.5.1.2 The Synergistic Effect of NO and Anticancer Drugs; 1.5.1.3 NO-NSAIDs as a New Generation of Anti-tumoral Agents; 1.5.1.4 Other NO Donors with Anticancer Activity; 1.5.2 NO against Virus; 1.5.2.1 HIV-1 Induces NO Production; 1.5.2.2 Antiviral and Proviral Activity of NO; 1.5.3 Inhibition of Bone Resorption; 1.5.4 Treatment of Diabetes; 1.5.5 Thromboresistant Polymeric Films; 1.5.6 Inhibition of Cysteine Proteases; 1.6 Conclusion; References; 2 Organic Nitrates and Nitrites; 2.1 Organic Nitrates2.1.1 Direct Chemical Reaction between Organic Nitrates and Thiols2.1.2 Glutathione-S-transferase; 2.1.3 Cytochrome P-450-dependent Systems; 2.1.4 Membrane-bound Enzyme of Vascular Smooth Muscle Cells; 2.1.5 Xanthine Oxidoreductase; 2.1.6 Mitochondrial Aldehyde Dehydrogenase; 2.1.7 Tolerance; 2.2 Organic Nitrites; 2.3 Conclusions; References; 3 N-Nitroso Compounds; 3.1 Introduction; 3.2 N-Nitrosamines; 3.2.1 Synthesis of Nitrosamines; 3.2.2 Physical Properties and Reactions of N-Nitrosamines; 3.2.3 Structure-Activity Relationship of N-Nitrosamines; 3.2.4 Application of N-Nitrosamines3.3 N-Hydroxy-N-nitrosoamines3.3.1 Biologically Active N-Hydroxy-N-nitrosamine Compounds; 3.3.2 Synthesis of N-Hydroxy-N-nitrosamines; 3.3.3 Properties of N-Hydroxy-N-nitrosamines; 3.3.4 Reactivity of N-Hydroxo-N-nitrosamines; 3.4 N-Nitrosimines; 3.4.1 Mechanism of Thermal Reaction of N-Nitrosoimine; 3.4.2 Properties of N-Nitrosoimines; 3.4.3 Synthesis of N-Nitrosoimines; 3.5 N-Diazeniumdiolates; 3.5.1 Mechanism of NO Release; 3.5.2 Synthesis of N-Diazeniumdiolates; 3.5.2.1 Ionic Diazeniumdiolates; 3.5.2.2 O-derivatized Diazeniumdiolates; 3.5.3 Reactions of N-Diazeniumdiolates3.5.4 Clinical Applications3.5.4.1 Reversal of Cerebral Vasospasm; 3.5.4.2 Treatment of Impotency; 3.5.4.3 Nonthrombogenic Blood-contact Surfaces; 3.5.5 Future Directions; References; 4 The Role of S-Nitrosothiols in the Biological Milieu; 4.1 Structure and Cellular Reactivity of RSNOs; 4.1.1 RSNO Structure; 4.1.1.1 Enzymatic Consumption of RSNOs; 4.1.2 Formation of RSNOs in the Biological Milieu; 4.1.2.1 Nitrite Mediated; 4.1.2.2 NO Mediated; 4.1.2.3 NO Oxidation Products Mediated; 4.1.2.4 Metalloprotein Mediated; 4.1.2.5 Transnitrosation; 4.2 Postulated Physiological roles of RSNOs4.2.1 Regulation of Blood Flow by HbSNONitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes.In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further therapeutic targets for these substances.Nitric oxideNitric oxidePhysiological effectDrugsDesignPharmaceutical chemistryNitric oxide.Nitric oxidePhysiological effect.DrugsDesign.Pharmaceutical chemistry.572.54Wang Peng George738023Cai Tingwai Bill1837635Taniguchi Naoyuki1942-1837636MiAaPQMiAaPQMiAaPQBOOK9911019353703321Nitric oxide donors4416398UNINA