01479oam 2200421zu 450 991037575550332120210807001957.0(CKB)3170000000001761(SSID)ssj0000812344(PQKBManifestationID)12391167(PQKBTitleCode)TC0000812344(PQKBWorkID)10859867(PQKB)11714490(Association for Computing Machinery)10.1145/267825(EXLCZ)99317000000000176120160829d1997 uy engurnn|008mam|atxtccrGIS 97: GIS 97: 5th International Workshop on Advances in Geographic Information Systems[Place of publication not identified]Association for Computing Machinery19971 online resource (78 p.;) ACM ConferencesBibliographic Level Mode of Issuance: Monograph1-58113-017-1 ACM ConferencesGIS '97Information TechnologyComputer Science (Hardware & Networks)Information TechnologyComputer Science (Hardware & Networks)Pissinou Niki937273Association for Computing Machinery-Digital Library.PQKBBOOK9910375755503321GIS 97: GIS 97: 5th International Workshop on Advances in Geographic Information Systems2216936UNINA03383nam 22005415 450 991088698830332120251113174921.03-031-66776-X10.1007/978-3-031-66776-3(MiAaPQ)EBC31648299(Au-PeEL)EBL31648299(CKB)34825782500041(DE-He213)978-3-031-66776-3(EXLCZ)993482578250004120240904d2024 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierAdrenoceptors /edited by Jillian G. Baker, Martin C. Michel, Roger J. Summers1st ed. 2024.Cham :Springer International Publishing :Imprint: Springer,2024.1 online resource (691 pages)Handbook of Experimental Pharmacology,1865-0325 ;2853-031-66775-1 Introduction: a short history of adrenoceptor research -- Structures of Adrenoceptors -- Genetic Variants of Adrenoceptors -- Adrenoceptors: Receptors, Ligands and Their Clinical Uses, Molecular Pharmacology and Assays -- Signalling of adrenoceptors: canonical pathways and new paradigms -- Presynaptic Adrenoceptors -- Roles of b-adrenoceptor subtypes and therapeutics in human cardiovascular disease:- heart failure, tachyarrhythmias and other cardiovascular disorders -- Adrenoceptors and Hypertension -- Adrenoceptors in the Lower Urinary Tract -- Asthma and COPD: A Focus on b-Agonists – Past, Present and Future -- Adrenoceptors in the Eye- Physiological and Pathophysiological Relevance -- Adrenoceptors: A Focus on Psychiatric Disorders and Their Treatments -- Locus Coeruleus and Noradrenergic Pharmacology in Neurodegenerative Disease -- Clinical use of adrenergic receptor ligands in acute care settings -- Adrenoceptor expression and function in the endocrine pancreas -- b-adrenoceptors in cancer: old players and new perspectives.Adrenoceptors have been at the forefront of physiological and pharmacological research for a century. They served as prototypes for rationale drug design as recognized by a Nobel Prize to Sir James Black and for the molecular understanding and structure of G protein-coupled receptors as recognized by a Nobel Prize to Brian Kobilka and Robert J. Lefkowitz. Drugs directly or indirectly targeting adrenoceptors have become guideline-recommended treatments for more than 30 human and various animal diseases. This volume assembles leading experts on various types of adrenoceptor research to provide concise insight into the current standing and future direction of uses of adrenoceptor-targeted drugs and research in this field.Handbook of Experimental Pharmacology,1865-0325 ;285PharmacologyDrugsDesignPharmacologyStructure-Based Drug DesignPharmacology.DrugsDesign.Pharmacology.Structure-Based Drug Design.615Baker Jillian G1768466Michel Martin C1768467Summers Roger J1768468MiAaPQMiAaPQMiAaPQBOOK9910886988303321Adrenoceptors4229449UNINA