04982nam 2200625Ia 450 991087779550332120200520144314.01-280-72336-X97866107233623-527-60818-43-527-60790-0(CKB)1000000000377114(EBL)481528(OCoLC)609855333(SSID)ssj0000299577(PQKBManifestationID)11196163(PQKBTitleCode)TC0000299577(PQKBWorkID)10242549(PQKB)10091944(MiAaPQ)EBC481528(EXLCZ)99100000000037711420050317d2006 uy 0engur|n|---|||||txtccrIndustrial biotransformations /edited by Andreas Liese, Karsten Seelbach, Christian Wandrey2nd completely rev and extened ed.Weinheim Wiley-VCH ;Chichester John Wiley [distributor]20061 online resource (572 p.)Previous ed.: 2000.3-527-31001-0 Includes bibliographical references and index.Industrial Biotransformations; Contents; Preface to the first edition; Preface to the second edition; List of Contributors; 1 History of Industrial Biotransformations - Dreams and Realities; 1.1 From the "Flower of Vinegar" to Recombinant E. Coli - The History of Microbial Biotransformations; 1.2 From Gastric Juice to SweetzymeT - The History of Enzymatic Biotransformations; 1.3 From Wine Bottle to a State-of-the-Art Facility - The History of Biochemical Engineering; 1.4 Advantages of Biotransformations Over Classical Chemistry Enzymes are proteins, things of beauty and a joy forever [40]2 The Enzyme Classification2.1 Enzyme Nomenclature; 2.2 Enzyme Classes; 2.2.1 EC 1 Oxidoreductases; 2.2.2 EC 2 Transferases; 2.2.3 EC 3 Hydrolases; 2.2.4 EC 4 Lyases; 2.2.5 EC 5 Isomerases; 2.2.6 EC 6 Ligases; 3 Retrosynthetic Biocatalysis; 3.1 Alkanes; 3.2 Alkenes; 3.3 Amines; 3.4 Alcohols; 3.5 Aldehydes; 3.6 Ketones; 3.7 Epoxides; 3.8 Diols; 3.9 Carboxylic Acids; 3.10 Esters; 3.11 Amides; 3.12 Imines; 3.13 Amino Acids; 3.14 Hydroxy Acids; 3.15 α-Hydroxy Ketones; 3.16 β-Hydroxy Aldehydes, Ketones or Carboxylic Acids; 3.17 Cyanohydrins, Hemithioacetals and Hemiaminals3.18 Sulfoxides and Sulfones3.19 Halides; 3.20 Aromatics (Ring Functionalization); 3.21 Cyclic Compounds; 3.22 Carbohydrates; 3.23 Peroxides; 3.24 Isomers; 3.25 Examples of Retrosynthetic Biotransformations; 3.25.1 Example 1; 3.25.2 Example 2; 4 Optimization of Industrial Enzymes by Molecular Engineering; 4.1 Introduction; 4.2 Learning from Nature; 4.3 Enzyme Production Using Bacterial Expression Hosts; 4.4 Improvements to Enzymes by Molecular Engineering Techniques; 4.4.1 Rational Enzyme Design; 4.4.2 Directed Evolution; 4.4.3 Random Mutagenesis Methods4.5 Identification of Improved Enzyme Variants4.6 Conclusions and Future Prospects; 5 Basics of Bioreaction Engineering; 5.1 Definitions; 5.1.1 Process Definitions; 5.1.2 Definitions of Unit Operations; 5.2 Biocatalyst Kinetics; 5.2.1 Types of Biocatalysts; 5.2.2 Enzyme Structure; 5.2.3 Kinetics; 5.3 Basic Reactor Types and their Modes of Operation; 5.3.1 Mass and Energy Balances; 5.4 Biocatalyst Recycling and Recovery; 5.4.1 Entrapment; 5.4.2 Cross-linking; 5.4.3 Covalent Binding; 5.4.4 Membrane Filtration; 5.5 Reaction Parameters; 5.6 Scale-up of Bioreactors5.7 Recent Developments and Trends6 Processes; Oxireductases EC 1; Transferases EC 2; Hydrolases EC 3; Lyases EC 4; Isomerases EC 5; 7 Quantitative Analysis of Industrial Biotransformations; Index; Index of enzyme name; Index of strain; Index of company; Index of starting material; Index of productThe completely revised second edition of this user-friendly and application-oriented overview of one-step biotransformations of industrial importance. Based on extensive literature and patent research, this book is unique in arranging each process in a systematic way to allow for easy comparison. All the chapters have been rewritten, with all the processes updated and more than 30 new processes added. Each set of data is accompanied by key literature citations, supported by flow sheets where available, reduced to their significant elements. In addition, an extensive index classified by subBiotransformation (Metabolism)Biochemical engineeringBiotransformation (Metabolism)Biochemical engineering.660.63Liese A(Andreas)879057Seelbach K(Karsten)724699Wandrey Christian1943-724698MiAaPQMiAaPQMiAaPQBOOK9910877795503321Industrial biotransformations4203159UNINA