05218nam 2200625 a 450 991087775100332120200520144314.01-283-30235-797866133023593-527-64399-03-527-63166-63-527-63167-4(CKB)2550000000056300(EBL)819502(OCoLC)774491993(SSID)ssj0000550557(PQKBManifestationID)11341224(PQKBTitleCode)TC0000550557(PQKBWorkID)10505210(PQKB)11465294(MiAaPQ)EBC819502(EXLCZ)99255000000005630020111128d2011 uy 0engur|n|---|||||txtccrModern drying technologyVolume 3Product quality and formulation /edited by Evangelos Tsotsas and Arun S. MujumdarWeinheim, Germany Wiley-VCH Verlag GmbH & Co.20111 online resource (432 p.)Modern Drying TechnologyDescription based upon print version of record.3-527-31558-6 Includes bibliographical references and index.Modern Drying Technology: Product Quality and Formulation; Contents; Series Preface; Preface of Volume 3; List of Contributors; Recommended Notation; EFCE Working Party on Drying: Address List; 1 Quality Changes in Food Materials as Influenced by Drying Processes; 1.1 Introduction; 1.2 Biochemical Reactions Induced by Drying; 1.3 Physical Transformations During Drying; 1.4 Mechanical Transformations Induced by Drying; 1.5 Storage and Rehydration of Food Products; 1.6 Conclusion; References; 2 Impact of Drying on the Mechanical Properties and Crack Formation in Rice; 2.1 Introduction2.2 Impact of Drying Conditions on Head Rice Yield for Paddy and Parboiled Rice2.3 Characterization of Fissures Formation by Image Analysis Techniques; 2.4 Characterization of the Mechanical Properties of the Rice Material; 2.4.1 Stress-Strain Relationships for Linear Materials; 2.4.2 Failure Strength in Rice Grains; 2.5 Modeling the Impact of Drying on the Final Quality of Rice Grains; 2.6 Conclusion; References; 3 Characterization and Control of Physical Quality Factors During Freeze-Drying of Pharmaceuticals in Vials; 3.1 Introduction3.2 Characterization Methods of the Key Quality Factors During Freeze-Drying of Pharmaceuticals in Vials3.2.1 State Diagram, Melting Curves, Vitreous Transition, Collapse Temperature; 3.2.2 Characterization Methods: DSC, MDSC, Freeze-Drying Microscopy; 3.2.3 Ice Structure and Morphology: Cold Chamber Optical Microscopy; 3.2.4 Heat Flux Heterogeneity in the Sublimation Chamber; 3.2.5 Permeability of Freeze-Drying Cake: Pressure Rise Tests; 3.2.6 Estimation of Mean Product Temperature; 3.3 Influence of Freezing and Freeze-Drying Parameters on Physical Quality Factors3.3.1 Influence of Freezing Protocol on Ice Morphology3.3.1.1 Influence of Freezing Rate; 3.3.1.2 Influence of Vial Type and Filling Height; 3.3.1.3 Annealing; 3.3.2 Controlled Nucleation; 3.3.2.1 Controlled Nucleation by Ultrasound Sonication; 3.3.2.2 Effect of Ultrasound on Structural and Morphological Properties; 3.3.3 Relationship between Nucleation Temperatures and Sublimation Rates; 3.3.4 Freeze-Dried Cake Morphology; 3.3.4.1 Water Vapor Mass Transfer Resistance; 3.3.4.2 Freeze-Dried Layer Permeability; 3.3.5 Importance of Temperature Control3.3.6 Influence of Operating Conditions on Sublimation Kinetics3.4 Product Quality and Stability During Drying and Storage; 3.4.1 Product Quality and Formulation; 3.4.2 Product Quality and Polymorphism; 3.5 Conclusions; References; 4 In-Line Product Quality Control of Pharmaceuticals In Freeze-Drying Processes; 4.1 Introduction; 4.2 Control of the Freezing Step; 4.3 Monitoring of the Primary Drying; 4.3.1 Monitoring of Single Vials; 4.3.2 Monitoring of a Group of Vials; 4.3.3 Monitoring of the Whole Batch; 4.3.3.1 Detection of the Endpoint of the Primary Drying4.3.3.2 Monitoring the Primary Drying Using the Measurement of the Sublimation FluxThis five-volume series provides a comprehensive overview of all important aspects of modern drying technology, concentrating on the transfer of cutting-edge research results to industrial use.Volume 3 deals with product quality and formulation. Biochemical, physical, and mechanical transformations which can occur during drying are described as well as methods for monitoring product quality such as process analytical technology. The preservation of desired product properties is disucssed in detail for foods and biomaterials, freeze-dried active pharmaceutical ingredients, and highly porousModern Drying TechnologyDryingDrying.303.625Tsotsas Evangelos907075Mujumdar A. S15607MiAaPQMiAaPQMiAaPQBOOK9910877751003321Modern drying technology3985603UNINA