03863nam 2200613Ia 450 991087730110332120200520144314.01-280-41117-197866104111770-470-03500-50-470-03499-8(CKB)1000000000357399(EBL)255723(SSID)ssj0000245851(PQKBManifestationID)11211418(PQKBTitleCode)TC0000245851(PQKBWorkID)10181220(PQKB)10013973(MiAaPQ)EBC255723(OCoLC)86221676(EXLCZ)99100000000035739920050331d2006 uy 0engur|n|---|||||txtccrSignalling pathways in acute oxygen sensingChichester, UK ;Hoboken, NJ John Wiley20061 online resource (302 p.)Novartis Foundation symposium ;272Description based upon print version of record.0-470-01457-1 Includes bibliographical references and indexes.Cover; Contents; Chair's introduction; Regulation of gene expression by HIF-1; DISCUSSION; Regulation of HIF: prolyl hydroxylases; DISCUSSION; General discussion I; Regulation of HIF: asparaginyl hydroxylation; DISCUSSION; Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells; DISCUSSION; The role of TASK-like K+ channels in oxygen sensing in the carotid body; DISCUSSION; Reactive oxygen species facilitate oxygen sensing; DISCUSSION; Oxygen sensing in neuroepithelial and adrenal chromaffin cells; DISCUSSIONHypoxic regulation of Ca2+ signalling in astrocytes and endothelial cellsDISCUSSION; General discussion II; Functional proteomics of BK potassium channels: defining the acute oxygen sensor; DISCUSSION; A central role for oxygen-sensitive K+ channels and mitochondria in the specialized oxygen-sensing system; DISCUSSION; Role for mitochondrial reactive oxygen species in hypoxic pulmonary vasoconstriction; DISCUSSION; Hypoxic pulmonary vasoconstriction-triggered by an increase in reactive oxygen species?; DISCUSSION; General discussion IIIThe role of twin pore domain and other K+ channels in hypoxicpulmonary vasoconstrictionDISCUSSION; AMP-activated protein kinase couples mitochondrial inhibition by hypoxia to cell-specific Ca2+ signalling mechanisms in oxygen-sensing cells; DISCUSSION; Role of capacitative Ca2+ entry but not Na+/Ca2+ exchange in hypoxic pulmonary vasoconstriction in rat intrapulmonary arteries; DISCUSSION; Final general discussion; Index of contributors; Subject indexOxygen sensing is a key physiological function of many tissues, but the identity of the sensor, the signalling pathways linking the sensor to the effector, and the endpoint effector mechanisms are all subjects of controversy. This book evaluates the various mediators that have been proposed, including the mitochondria, NAD(P)H oxidases, cytochrome p450 enzymes, and direct effects on enzymes and ion channels. There has been a resurgence of interest in the role of mitochondria, based partly on the ability of mitochondrial inhibitors to mimic hypoxia, but there is little consensus concerning mechNovartis Foundation symposium ;272.Oxygen in the bodyOxygenOxygen in the body.Oxygen.572.53573.1536Novartis Foundation.Symposium on Signalling Pathways in Acute Oxygen SensingMiAaPQMiAaPQMiAaPQBOOK9910877301103321Signalling pathways in acute oxygen sensing4193069UNINA