02594nam 2200613 a 450 991087728480332120200520144314.03-527-63349-91-283-28324-797866132832453-527-63347-23-527-63348-0(CKB)2550000000054248(EBL)700863(SSID)ssj0000507332(PQKBManifestationID)11303298(PQKBTitleCode)TC0000507332(PQKBWorkID)10546561(PQKB)11749187(MiAaPQ)EBC700863(OCoLC)729724693(EXLCZ)99255000000005424820111111d2011 uy 0engur|n|---|||||txtccrProtein kinases as drug targets /edited by Bert Klebl, Gerhard Muller, and Michael Hamacher2nd ed.Weinheim, Germany Wiley-VCH20111 online resource (398 p.)Methods and principles in medicinal chemistry ;v. 49Description based upon print version of record.3-527-31790-2 Includes bibliographical references and index.pt. 1. Hit finding and profiling for protein kinases : assay development and screening, libraries -- pt. 2. Medicinal chemistry -- pt. 3. Application of kinase inhibitors to therapeutic indication areas.This timely guide to kinase inhibitor drug development is the first to cover the entire drug pipeline, from target identification to compound development and clinical application. Edited by the pioneers in the field, on the drug development side this ready reference discusses classical medicinal chemistry approaches as well as current chemical genomics strategies. On the clinical side, both current and future therapeutic application areas for kinase inhibitor drugs are addressed, with a strong focus on oncology drugs.Backed by recent clinical experience with first-generation drugs in the bMethods and principles in medicinal chemistry ;v. 49.Protein kinasesDrugsDesignProtein kinases.DrugsDesign.615.19Muller Gerhard27342Klebl Bert1755070Hamacher Michael1755071MiAaPQMiAaPQMiAaPQBOOK9910877284803321Protein kinases as drug targets4191691UNINA