02420nam 22005534a 450 991087718880332120200520144314.01-282-34870-197866123487090-470-51665-80-470-51664-X(CKB)1000000000377226(EBL)470311(OCoLC)723943532(SSID)ssj0000297181(PQKBManifestationID)11224577(PQKBTitleCode)TC0000297181(PQKBWorkID)10328488(PQKB)10142932(MiAaPQ)EBC470311(EXLCZ)99100000000037722620070608d2007 uy 0engur|n|---|||||txtccrG protein-coupled receptors molecular pharmacology from academic concept to pharmaceutical research /Georges Vauquelin, Bengt von MentzerChichester, England ;Hoboken, NJ John Wiley & Sonsc20071 online resource (266 p.)Description based upon print version of record.0-470-51647-X Includes bibliographical references (p. [235]-243) and index.Chemical messengers and the cell membrane -- Radioligand binding studies -- Functional studies -- G protein-coupled receptors -- Concluding remarks.G protein-coupled receptors (GPCRs) are membrane proteins that transduce a vast array of extracellular signals into intracellular reactions ranging from cell-cell communication processes to physiological responses. They play an important role in a variety of diseases from cancer and diabetes, to neurodegenerative, inflammatory and respiratory disorders. GPCRs are therefore of utmost interest in drug development: over half of all prescription drugs currently on the market act by targeting these receptors directly or indirectly. G Protein-coupled Receptors: Molecular Pharmacology proviG proteinsReceptorsMolecular pharmacologyG proteinsReceptors.Molecular pharmacology.615/.1Vauquelin Georges1754473Mentzer Bengt von1754474MiAaPQMiAaPQMiAaPQBOOK9910877188803321G protein-coupled receptors4190892UNINA