02919nam 22005774a 450 991087697320332120200520144314.01-281-32178-897866113217890-470-72430-70-470-72429-3(CKB)1000000000377090(EBL)351029(SSID)ssj0000127651(PQKBManifestationID)11140059(PQKBTitleCode)TC0000127651(PQKBWorkID)10061929(PQKB)10478583(MiAaPQ)EBC351029(PPN)152256075(OCoLC)184983256(EXLCZ)99100000000037709020070928d2007 uy 0engur|n|---|||||txtccrComputational methods for mass spectrometry proteomics /Ingvar Eidhammer ... [et al.]Chichester, England ;Hoboken, NJ John Wiley & Sonsc20071 online resource (298 p.)Description based upon print version of record.0-470-51297-0 Includes bibliographical references (p. [265]-275) and index.Protein, proteome, and proteomics -- Protein separation : 2D gel electrophoresis -- Protein digestion -- Peptide separation : HPLC -- Fundamentals of mass spectrometry -- Mass spectrometry : MALDI-TOF -- Protein identification and characterization by MS -- Tandem MS or MS/MS analysis -- Fragmentation models -- Identification and characterization by MS/MS -- Spectral comparisons -- Sequential comparison : de novo sequencing -- Database searching for de novo sequences -- Large-scale proteomics -- Quantitative MS-based proteomics -- Peptides to proteins -- Top-down proteomics -- Standards.Proteomics is the study of the subsets of proteins present in different parts of an organism and how they change with time and varying conditions. Mass spectrometry is the leading technology used in proteomics, and the field relies heavily on bioinformatics to process and analyze the acquired data. Since recent years have seen tremendous developments in instrumentation and proteomics-related bioinformatics, there is clearly a need for a solid introduction to the crossroads where proteomics and bioinformatics meet. Computational Methods for Mass Spectrometry Proteomics describProteomicsData processingMass spectrometryData processingBioinformaticsProteomicsData processing.Mass spectrometryData processing.Bioinformatics.572/.60285Eidhammer Ingvar1751303MiAaPQMiAaPQMiAaPQBOOK9910876973203321Computational methods for mass spectrometry proteomics4203105UNINA