03919nam 2200649Ia 450 991087651820332120200520144314.01-282-34597-497866123459750-470-51361-60-470-51362-4(CKB)1000000000377242(EBL)470442(SSID)ssj0000304622(PQKBManifestationID)11263482(PQKBTitleCode)TC0000304622(PQKBWorkID)10278095(PQKB)10924396(MiAaPQ)EBC470442(OCoLC)181170295(EXLCZ)99100000000037724219871104d1988 uy 0engur|n|---|||||txtccrNovel infectious agents and the central nervous systemChichester ;New York Wiley19881 online resource (290 p.)Ciba Foundation symposium ;135"A Wiley-Interscience publication."Papers and discussions from the Symposium on Novel Infectious Agents and the Central Nervous System, held at the Ciba Foundation, London, June 30-July 2, 1987.0-471-91512-2 Includes bibliographies and indexes.NOVEL INFECTIOUS AGENTSANDTHE CENTRAL NERVOUS SYSTEM; Contents; Participants; Introduction; The clinical neurology and epidemiology of Creutzfeldt-Jakob disease, with special reference to iatrogenic cases; Neuropathology of unconventional virus infections: molecu lar pathology of spongiform change and amyloid plaque deposit ion; Pathogenesis of experimental scrapie; Genetic aspects of unconventional virus infections: the basis of the virino hypothesis; Genetic control of prion incubation period in mice; Developmental regulation of prion protein mRNA in brainPotential involvement of retroviral elements in human dementiasScrapie: a virus-induced amyloidosis of the brain; Scrapie-associated fibrils, PrP protein and the Sinc gene; A modified host protein model of scrapie; Properties of scrapie prion proteins in liposomes and amyloid rods; In vitro expression of cloned PrP cDNA derived from scrapie-infected mouse brain: lack of transmission of scrapie infectivity; Search for a scrapie-specific nucleic acid: a progress report; Pathogenesis of amyloid formation in Alzheimer's disease, Down's syndrome and scrapieNovel mechanisms of degeneration of the central newous system - prion structure and biologyFinal general discussion; Summary; Index of contributors; Subject indexThe term ``unconventional virus'' refers to virus-like agents that differ from conventional viruses in significant respects--resistance to agents that inactivate normal viruses, for example. Certain rare and fatal neurological disorders, such as the Creutzfeldt-Jacob syndrome and the Gerstmann-Straussler syndrome, are clearly produced by virus-like infectious agents, but the nature of these agents is not understood. This volume brings together the latest information on one such disease: Scrapie, a disease occurring in sheep. It discusses the nature of this infectious agent and insights gained Ciba Foundation symposium ;135.Central nervous systemDiseasesEtiologyCongressesScrapieCongressesPrionsCongressesCentral nervous systemDiseasesEtiologyScrapiePrions616.8616.83Ciba Foundation.Symposium on Novel Infectious Agents and the Central Nervous System(1987 :Ciba Foundation)MiAaPQMiAaPQMiAaPQBOOK9910876518203321Novel infectious agents and the central nervous system898546UNINA