03839nam 22006735 450 991086524100332120250220142229.09783031440878(electronic bk.)978303144086110.1007/978-3-031-44087-8(MiAaPQ)EBC31496597(Au-PeEL)EBL31496597(CKB)32317897700041(DE-He213)978-3-031-44087-8(EXLCZ)993231789770004120240617d2024 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierCongenital Heart Diseases: The Broken Heart Clinical Features, Human Genetics and Molecular Pathways /edited by Silke Rickert-Sperling, Robert G. Kelly, Nikolaus Haas2nd ed. 2024.Cham :Springer International Publishing :Imprint: Springer,2024.1 online resource (1098 pages)Advances in Experimental Medicine and Biology,2214-8019 ;1441Print version: Rickert-Sperling, Silke Congenital Heart Diseases: the Broken Heart Cham : Springer International Publishing AG,c2024 9783031440861 Includes bibliographical references and index.Section I: General introduction in cardiac development -- Section II: Different chapters covering the different types of congenital heart disease -- Section III: The overall perspective.This 2nd edition has been extensively updated and provides comprehensive and current insight into congenital heart diseases, from embryonic development through to clinical features, including human genetics and our current knowledge of the underlying molecular pathways. The book is divided into three parts: an introduction to the development of the heart and its vessels, an overview of the molecular pathways affecting the development of various cardiovascular structures, and a main section focusing on the different types of structural and nonstructural congenital heart diseases, including their clinical features, underlying genetic alterations and insights from animal models and pathways. All chapters have been updated and new chapters added on state-of-the-art approaches including stem cells and organoids, cardiac metabolism, single cell transcriptomics and 3D reconstruction of human heart development. The clinical chapters have been extended and include new sections on diagnostic imaging techniques. Taken together, the book, written by and for clinicians and researchers, provides an integrated and up-to-date resource for all those who want to learn more about both the clinical aspects and the genetic and molecular basis of congenital heart disease. Chapter 11 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.Advances in Experimental Medicine and Biology,2214-8019 ;1441Medical geneticsMedicineResearchBiologyResearchCardiologyMedicineMedical GeneticsBiomedical ResearchCardiologyClinical MedicineMedical genetics.MedicineResearch.BiologyResearch.Cardiology.Medicine.Medical Genetics.Biomedical Research.Cardiology.Clinical Medicine.616.12043Rickert-Sperling SilkeKelly R. G.Haas NikolausMiAaPQMiAaPQMiAaPQ9910865241003321Congenital Heart Diseases: The Broken Heart2494341UNINA