04101nam 22005055 450 991031194000332120200703114556.03-030-03526-310.1007/978-3-030-03526-6(CKB)4100000007598572(MiAaPQ)EBC5683098(DE-He213)978-3-030-03526-6(PPN)23500670X(EXLCZ)99410000000759857220190205d2018 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierThe Sliding-Filament Theory of Muscle Contraction /by David Aitchison Smith1st ed. 2018.Cham :Springer International Publishing :Imprint: Springer,2018.1 online resource (433 pages)3-030-03525-5 Understanding the molecular mechanism of muscle contraction started with the discovery that striated muscle is composed of interdigitating filaments which slide against each other. Sliding filaments and the working-stroke mechanism provide the framework for individual myosin motors to act in parallel, generating tension and loaded shortening with an efficient use of chemical energy. Our knowledge of this exquisitely structured molecular machine has exploded in the last four decades, thanks to a bewildering array of techniques for studying intact muscle, muscle fibres, myofibrils and single myosin molecules. After reviewing the mechanical and biochemical background, this monograph shows how old and new experimental discoveries can be modelled, interpreted and incorporated into a coherent mathematical theory of contractility at the molecular level. The theory is applied to steady-state and transient phenomena in muscle fibres, wing-beat oscillations in insect flight muscle, motility assays and single-molecule experiments with optical trapping. Such a synthesis addresses major issues, most notably whether a single myosin motor is driven by a working stroke or a ratchet mechanism, how the working stroke is coupled to phosphate release, and whether one cycle of attachment is driven by the hydrolysis of one molecule of ATP. Ways in which the theory can be extended are explored in appendices. A separate theory is required for the cooperative regulation of muscle by calcium via tropomyosin and troponin on actin filaments. The book reviews the evolution of models for actin-based regulation, culminating in a model motivated by cryo-EM studies where tropomyosin protomers are linked to form a continuous flexible chain. It also explores muscle behaviour as a function of calcium level, including emergent phenomena such as spontaneous oscillatory contractions and direct myosin regulation by its regulatory light chains. Contraction models can be extended to all levels of calcium-activation by embedding them in a cooperative theory of thin-filament regulation, and a method for achieving this grand synthesis is proposed. Dr. David Aitchison Smith is a theoretical physicist with thirty years of research experience in modelling muscle contractility, in collaboration with experimental groups in different laboratories.Human physiologyMolecular biologyCell physiologyHuman Physiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B13004Molecular Medicinehttps://scigraph.springernature.com/ontologies/product-market-codes/B1700XCell Physiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L33010Human physiology.Molecular biology.Cell physiology.Human Physiology.Molecular Medicine.Cell Physiology.612573.75Aitchison Smith Davidauthttp://id.loc.gov/vocabulary/relators/aut1062911BOOK9910311940003321The Sliding-Filament Theory of Muscle Contraction2529080UNINA04506nam 22006015 450 991084249740332120250807143314.0981-9703-12-310.1007/978-981-97-0312-8(MiAaPQ)EBC31202422(Au-PeEL)EBL31202422(DE-He213)978-981-97-0312-8(CKB)30787992500041(EXLCZ)993078799250004120240306d2024 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierFlexible Load Control for Enhancing Renewable Power System Operation /by Yuanzheng Li, Yang Li, Zhigang Zeng1st ed. 2024.Singapore :Springer Nature Singapore :Imprint: Springer,2024.1 online resource (288 pages)Power Systems,1860-4676981-9703-11-5 Includes bibliographical references.Chapter 1. Overview of flexible load control -- Chapter 2. Data center flexible load control for renewable energy integration -- Chapter 3. Data center load control based microgrid operation via robust multi-objective optimization -- Chapter 4. Collaborative control of data center and hydrogen storage system for renewable energy absorption -- Chapter 5. Flexible industrial load control for renewable power system operation -- Chapter 6. A demand-supply cooperative responding control of industrial load and renewable power system -- Chapter 7. Electric vehicle flexible charging load control for renewable power system operation -- Chapter 8. Battery swapping control for centralized electric vehicle charging system with photovoltaic -- Chapter 9. Coordinated Operation Between Electric Vehicle Charging Stations and Distribution Power Network Considering Energy and Reserve -- Chapter 10. Flexible integrated load control based comprehensive energy system operation -- Chapter 11. Data-driven distributionally robust scheduling of community comprehensive energy systems considering integrated load control -- Chapter 12. Concluding remarks.This book addresses the pressing challenges faced by renewable power system operation (RPSO) due to the increasing penetration of renewable energy and flexible load. These challenges can be divided into two categories. Firstly, the inherent uncertainties associated with renewable energy sources pose significant difficulties in RPSO. Secondly, the presence of various types of flexible load, along with their complex constraint relationships, adds to the operational complexities. Recognizing the growing emphasis on the economic and low-carbon aspects of RPSO, this book focuses on the key issues of flexible load control. It mainly consists of following categories: (1) The control of data centers, a booming flexible load, to enhance RPSO through renewable energy integration and advanced robust multi-objective optimization. (2) The introduction of flexible industrial load control, employing effective demand-supply cooperative responding strategies for RPSO. (3) The exploration of electric vehicle flexible charging load control and centralized electric vehicle charging system control in the context of RPSO. The book also covers the emerging field of flexible integrated load control for renewable energy-based comprehensive energy system operation. Aimed at researchers, engineers, and graduate students in electrical engineering and computer science, this book provides a valuable resource for understanding and implementing flexible load control in the context of RPSO.Power Systems,1860-4676Electric power distributionAutomatic controlArtificial intelligenceEnergy Grids and NetworksControl and Systems TheoryArtificial IntelligenceElectric power distribution.Automatic control.Artificial intelligence.Energy Grids and Networks.Control and Systems Theory.Artificial Intelligence.621.31Li Yuanzheng1370159Li YangTseng TommasoMiAaPQMiAaPQMiAaPQBOOK9910842497403321Flexible Load Control for Enhancing Renewable Power System Operation4271773UNINA