02923nam 22005653 450 991084226350332120250905110031.09781040024959104002495597810400250001040025005(CKB)5600000000812035(MiAaPQ)EBC31281988(Au-PeEL)EBL31281988(MiAaPQ)EBC31281987(Au-PeEL)EBL31281987(OCoLC)1430657890(ODN)ODN0011069995(NjHacI)995600000000812035(EXLCZ)99560000000081203520240422d2024 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierFlipons The Discovery of Z-DNA and Soft-Wired Genomes1st ed.Milton :Taylor & Francis Group,2024.©2024.1 online resource (287 pages)9781032731087 1032731087 Cover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Table of Contents -- Preface -- Acknowledgements -- About the Author -- Part I -- Chapter 1 The Dawn -- What Is DNA? -- In the Beginning -- Chapter 2 Even Smart People Are Sometimes Wrong -- The First Sighting of Left-handed Z-DNA -- Chapter 3 Coming to America -- Chapter 4 From One Unknown to Another -- Chapter 5 Failing Successfully Everywhere Else: The In-between Years -- The Framingham Years -- The Merck Experience -- Chapter 6 How Do You Know It's You? The Answer Lies in Your Z-RNA -- Chapter 7 Can Left-handed Z-DNA and Z-RNA Kill You? -- Chapter 8 Does Z-DNA Regulate Transcription? -- Chapter 9 Luck and the Business of Science -- Part II -- Chapter 10 What about Other Types of Flipons? -- Other Types of Flipons -- G-flipons -- T-flipons -- L-flipons -- Chapter 11 Is Your Genome Soft-wired? -- Shaping DNA with RNA -- Chapter 12 How Do You Assemble a Soft-wired Genome? -- Peptide Patches -- Peptide Patches and Evolution -- Chapter 13 How Do You Program a Soft-wired Genome? -- Chapter 14 Is Life Intransitive? -- Chapter 15 Are RNA Therapeutics the Wave of the Future? -- Epilogue: Why Have a Career in Science? -- References -- Index.Alan Herbert has played a leading part in discovering the biological roles for a high-energy form of DNA twisted to the left rather than to the right. Both Z-DNA and the Z-RNA sensing proteins are critical for protecting hosts against both viruses and cancers.GenomicsGene mappingGenomesGenomics.Gene mapping.Genomes.572.86Herbert Alan1852698MiAaPQMiAaPQMiAaPQBOOK9910842263503321Flipons4448580UNINA