05258nam 2200649Ia 450 991084161060332120230607213228.01-280-27001-297866102700190-470-36526-90-470-85419-70-470-85420-0(CKB)111056485604306(EBL)139832(OCoLC)53880472(SSID)ssj0000201562(PQKBManifestationID)11201868(PQKBTitleCode)TC0000201562(PQKBWorkID)10245518(PQKB)11112141(MiAaPQ)EBC139832(EXLCZ)9911105648560430620020523d2002 uy 0engurcn|||||||||txtccrMeta-analysis of controlled clinical trials[electronic resource] /Anne WhiteheadChichester ;Hoboken, NJ John Wiley & Sonsc20021 online resource (353 p.)Statistics in practiceDescription based upon print version of record.0-471-98370-5 Includes bibliographical references (p. 321-328) and index.Meta-Analysis of Controlled Clinical Trials; Statistics in Practice; Contents; Preface; 1 Introduction; 1.1 The role of meta-analysis; 1.2 Retrospective and prospective meta-analyses; 1.3 Fixed effects versus random effects; 1.4 Individual patient data versus summary statistics; 1.5 Multicentre trials and meta-analysis; 1.6 The structure of this book; 2 Protocol development; 2.1 Introduction; 2.2 Background; 2.3 Objectives; 2.4 Outcome measures and baseline information; 2.5 Sources of data; 2.6 Study selection; 2.7 Data extraction; 2.8 Statistical analysis; 2.8.1 Analysis population2.8.2 Missing data at the subject level 2.8.3 Analysis of individual trials; 2.8.4 Meta-analysis model; 2.8.5 Estimation and hypothesis testing; 2.8.6 Testing for heterogeneity; 2.8.7 Exploration of heterogeneity; 2.9 Sensitivity analyses; 2.10 Presentation of results; 3 Estimating the treatment difference in an individual trial; 3.1 Introduction; 3.2 Binary data; 3.2.1 Example: Stroke in hypertensive patients; 3.2.2 Measurement of treatment difference; 3.3 Survival data; 3.3.1 Example: Mortality following myocardial infarction; 3.3.2 Measurement of treatment difference3.4 Interval-censored survival data 3.4.1 Example: Ulcer recurrence; 3.4.2 Measurement of treatment difference; 3.5 Ordinal data; 3.5.1 Example: Global impression of change in Alzheimer's disease; 3.5.2 Measurement of treatment difference; 3.6 Normally distributed data; 3.6.1 Example: Recovery time after anaesthesia; 3.6.2 Measurement of treatment difference; 4 Combining estimates of a treatment difference across trials; 4.1 Introduction; 4.2 A general fixed effects parametric approach; 4.2.1 A fixed effects meta-analysis model4.2.2 Estimation and hypothesis testing of the treatment difference 4.2.3 Testing for heterogeneity across studies; 4.2.4 Obtaining the statistics via weighted least-squares regression; 4.2.5 Example: Stroke in hypertensive patients; 4.2.6 Example: Mortality following myocardial infarction; 4.2.7 Example: Ulcer recurrence; 4.2.8 Example: Global impression of change in Alzheimer's disease; 4.2.9 Example: Recovery time after anaesthesia; 4.3 A general random effects parametric approach; 4.3.1 A random effects meta-analysis model4.3.2 Estimation and hypothesis testing of the treatment difference 4.3.3 Estimation of t(2) using the method of moments; 4.3.4 Obtaining the statistics via weighted least-squares regression; 4.3.5 Example: Mortality following myocardial infarction; 4.3.6 Example: Global impression of change in Alzheimer's disease; 4.3.7 Example: Recovery time after anaesthesia; 4.3.8 A likelihood approach to the estimation of t(2); 4.3.9 Allowing for the estimation of t(2); 5 Meta-analysis using individual patient data; 5.1 Introduction; 5.2 Fixed effects models for normally distributed data5.2.1 A fixed effects meta-analysis modelOver the last twenty years there has been a dramatic upsurge in the application of meta-analysis to medical research. This has mainly been due to greater emphasis on evidence-based medicine and the need for reliable summaries of the vast and expanding volume of clinical research. At the same time there have been great strides in the development and refinement of the associated statistical methodology. This book describes the planning, conduct and reporting of a meta-analysis as applied to a series of randomized controlled clinical trials.* The various approaches are presented within a geneStatistics in practice.Clinical trialsStatistical methodsMeta-analysisClinical trialsStatistical methods.Meta-analysis.610/.7/27615.19Whitehead Anne939635MiAaPQMiAaPQMiAaPQBOOK9910841610603321Meta-analysis of controlled clinical trials4139144UNINA