04290nam 2200613Ia 450 991084072720332120230607221537.01-281-31179-097866113117973-527-62102-43-527-62103-2(CKB)1000000000408267(EBL)481897(OCoLC)609855478(SSID)ssj0000290038(PQKBManifestationID)11255023(PQKBTitleCode)TC0000290038(PQKBWorkID)10403753(PQKB)11490638(MiAaPQ)EBC481897(EXLCZ)99100000000040826720030613d2002 uy 0engur|n|---|||||txtccrBiological monitoring[electronic resource] prospects in occupational and environmental medicine : round table discussions and colloquia /edited by Jürgen Angerer (Discussion leader) and Tobias Weiss (editing)Bonn, Germany Deutsche Forschungsgemeinschaft ;Weinheim, Germany Wiley-VCHc20021 online resource (213 p.)Description based upon print version of record.3-527-27795-1 Includes bibliographical references.Biological Monitoring Prospects in Occupational and Environmental Medicine; Contents; Foreword; 1 The Importance of Biological Monitoring; 1.1 The Development and Importance of Biological Monitoring in the DFG and MAK Commission; 2 Internal Exposure and Haemoglobin Adducts; 2.1 Biological Monitoring in Occupational and Environmental Medicine - The Present State of the Art and Future Prospects; 2.2 Metabolic Profiling - A Way of Better Understanding External and Internal Exposure to Organic Stubstances; 2.3 Biological Monitoring of Arylamines and Nitroarenes; 3 DNA Adducts3.1 Genetic Cancer Susceptibility and DNA Adducts: Studies in Smokers and Coke Oven Workers3.2 The Detection of DNA Adducts in Biological Monitoring; 3.3 (32)P-Postlabelling HPLC Analysis of DNA Adducts in Breast Tissue; 3.4 Studies of 8-Hydroxy-2 ́-Deoxyguanosine: A Biomarker for Oxidative DNA Damage in vivo?; 4 Susceptibility; 4.1 Improved Methods of Phenotyping and Effect Monitoring for Evaluating the Risk to the Individual, using GSTT1 as an Example; 4.2 Genetic Polymorphisms of Sulfotransferases as Susceptibility Parameters; 4.3 Genotyping and Phenotyping, Using NAT2 as an Example4.4 New High-thoughput Technology in the Diagnostic Screening of Susceptibility Factors5 Cytogenetic Parameters; 5.1 Biological Monitoring with Cytogenetic Methods; 5.2 Examples of the Use of Three-colour Chromosome Painting in Cytogenetic Biomonitoring; 5.3 The Comet Assay as a Biological Monitoring Test; 6 Immunology; 6.1 Immunoglobulins as Markers of Long-term Exposure to Allergenic Substances; 6.2 Immunological Effects of Polymorphic Key Enzymes; 7 Epidemiology; 7.1 Evaluation of Exposure in Epidemiological Studies7.2 Possibilities and Limitations of the Molecular Epidemiology of Workplace Exposures8 Summary; 9 Authors and ParticipantsAt the invitation of the Deutsche Forschungsgemeinschaft (DFG), a round-table discussion was held on 9 and 10 March 2000, dealing with future possibilities for biomonitoring in occupational and environmental medicine. Biomonitoring has reached a high standard in Germany over the past 30 years, not least due to the fact that the results of the Senate commission on materials hazardous to health at the workplace have been directly implemented as part of the jurisdiction relating to occupational safety.This book combines the expertise gathered from various areas within toxicology, occupatiBiological monitoringCongressesIndustrial toxicologyCongressesBiological monitoringIndustrial toxicology613.62615.902Angerer J98859Weiss Tobias1730005Deutsche Forschungsgemeinschaft.MiAaPQMiAaPQMiAaPQBOOK9910840727203321Biological Monitoring4140302UNINA