03752nam 2200409 450 991058307140332120221122002509.00-12-812560-80-12-812347-8(CKB)4100000004531239(MiAaPQ)EBC5426717(PPN)233903755(EXLCZ)99410000000453123920180628d2018 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierBipolar disorder vulnerability perspectives from pediatric and high-risk populations /edited by Jair C. Soares, Consuelo Walss-Bass, Paolo BrambillaLondon :Academic Press,2018.1 online resource (290 pages)The bipolar prodrome -- Staging models and neuroprogression in bipolar disorder -- Influence of early childhood trauma on risk for bipolar disorder -- Gene-environment interactions in high-risk populations -- Genetic risk in adult family members of patients with bipolar disorder -- Neurobiological markers of stress in youth at risk for bipolar disorder -- Neurobiological markers of stress in youth at risk for bipolar disorder -- Neuroimaging findings in youth at risk for bipolar disorder -- Neurocognitive findings in youth at high risk for bipolar disorder: potential endophenotypes? -- Neuropsychological and social cogitive function in young people at genetic risk of bipolar disorder -- Cognitive and neural basis of hypomania: perspectives for early detection of bipolar disorder -- Early pharmacological interventions in youth -- Psychological interventions in offspring of parents with bipolar disorder -- Summary and integration of current findings: a model for bipolar disorder developmentBipolar Disorder Vulnerability: Perspectives from Pediatric and High-Risk Populations synthesizes our current understanding of high-risk and pediatric populations to aid readers in identifying markers of vulnerability for the development of bipolar disorder, with an ultimate goal of the development of drug targets and other therapies for early diagnosis and treatment. The book provides readers with an understanding of biological and environmental factors influencing disease manifestation that will aid them in defining discrete clinical stages and, importantly, establish an empirical basis for the application of novel therapeutics in a phase of illness during which specific treatments could more effectively alter disease course. Whereas most of the literature available on the pathophysiological mechanisms of bipolar disorder focuses on chronically ill adult individuals, this represents the only book that specifically examines pediatric and high-risk populations. An estimated 30 to 60 percent of adult bipolar disorder patients have their disease onset during childhood, with early-onset cases representing a particularly severe and genetically loaded form of the illness.Highlights diverse translational methodologies, including functional and structural neuroimaging, neuropsychological testing and integrated genomicsExamines molecular trajectories in youth with bipolar disorder and unaffected youth at high risk for developing bipolar disorderExplores the interaction between genomic and environmental influences that shape behavior.Bipolar disorderEtiologyBipolar disorderEtiology.616.895Soares Jair C.Walss-Bass ConsueloBrambilla PaoloMiAaPQMiAaPQMiAaPQBOOK9910583071403321Bipolar disorder vulnerability2031028UNINA01580nam 2200529 450 991079698960332120200520144314.01-119-37965-2(CKB)3840000000342488(MiAaPQ)EBC5301741(JP-MeL)3000131711(Au-PeEL)EBL5301741(CaPaEBR)ebr11512961(OCoLC)1023575792(EXLCZ)99384000000034248820180308h20182018 uy 0engurcnu||||||||rdacontentrdamediardacarrierSU+RE sustainable + resilient design systems /guest-edited by John Nastasi, Ed May and Clarke SnellOxford, [England] :John Wiley & Sons,2018.20181 online resource (141 pages) color illustrations, photographsArchitectural Design ;Volume 88, 1Includes bibliographical references1-119-37951-2 Architectural design (London, England : 1971) ;Volume 88, 1.SU plus RESustainable architectureSustainable designSustainable architecture.Sustainable design.720.47525.1njb/09720.47njb/09Nastasi JohnMay EdSnell ClarkeMiAaPQMiAaPQMiAaPQBOOK9910796989603321SU+RE3729266UNINA03588oam 2200769 c 450 991083833740332120220221094418.03-657-70429-910.30965/97836577042939783506704290(CKB)4100000010861174(OCoLC)1137834217(nllekb)BRILL9783657704293(MiAaPQ)EBC6516810(Au-PeEL)EBL6516810(OCoLC)1243546780(Brill | Schöningh)9783657704293(EXLCZ)99410000001086117420220221d2020 uy 0gerurun####uuuuatxtrdacontentcrdamediardacarrierOtto BeisheimJugend, Soldatenzeit und Entwicklung zum HandelspionierJoachim Scholtyseck1st ed.PaderbornBrill | Schöningh20201 online resource3-506-70429-X Includes bibliographical references (pages 225-243) and index.Front Matter -- Copyright page -- Einleitung: Eine Unternehmerbiographie in der Debatte -- Unruhige Zeiten: Die Industrie- und Handelsstadt Mülheim an der Ruhr von 1918 bis 1939 -- Otto Beisheim – Herkunft, Familie und Kindheit -- Eine Jugend im „Dritten Reich“ -- Vom RAD zur Waffen-SS: Otto Beisheim im Zweiten Weltkrieg -- Otto Beisheim, das Kriegsende und die britische Kriegsgefangenschaft -- 1946: Ein beruflicher Neuanfang -- Eine „Vergangenheit, die nicht vergehen will“ -- Otto Beisheim und die öffentlichen Debatten um seine Zeit als Angehöriger der Waffen-SS -- Fazit -- Nachwort -- Back Matter -- Abkürzungsverzeichnis -- Quellen und Literatur -- Abbildungsnachweis -- Map -- Personenregister.Blick ins BuchDer 1924 in Mülheim an der Ruhr geborene Otto Beisheim war einer der Pioniere des deutschen Handels und ist besonders als Mitgründer des Cash & Carry-Großhändlers "Metro" bekannt, bei dem er 1964 im Alter von 40 Jahren geschäftsführender Gesellschafter wurde.Über seine Herkunft, seine Jugend im "Dritten Reich", seine Soldatenzeit in der Waffen-SS im Zweiten Weltkrieg, seine Kriegsgefangenschaft und seinen Werdegang in den Jahren des "deutschen Wirtschaftswunders" bis zu seinem Einstieg in die Handelsbranche informiert dieses Werk. Auch Beisheims eigener Umgang mit den Jahren der NS-Diktatur wird thematisiert.Metro-KonzernNachkriegszeitBundesrepublikWaffen-SSUnternehmensgeschichteWirtschaftsgeschichteMetro-GroßhandelZweiter WeltkriegMülheim an der RuhrWirtschaftswunderMetro Cash & Carry GroupSecond World WarEconomic MiracleGermanyEconomic conditions20th centuryMetro-KonzernNachkriegszeitBundesrepublikWaffen-SSUnternehmensgeschichteWirtschaftsgeschichteMetro-GroßhandelZweiter WeltkriegMülheim an der RuhrWirtschaftswunderMetro Cash & Carry GroupSecond World WarEconomic Miracle943Scholtyseck Joachimaut1276594NL-LeKBNL-LeKBBOOK9910838337403321Otto Beisheim4141176UNINA