04318nam 2200649Ia 450 991083107680332120230617021530.01-280-52066-397866105206643-527-60566-53-527-60178-3(CKB)1000000000019353(EBL)481536(OCoLC)68932384(SSID)ssj0000246906(PQKBManifestationID)11186333(PQKBTitleCode)TC0000246906(PQKBWorkID)10188583(PQKB)11192449(MiAaPQ)EBC481536(EXLCZ)99100000000001935320020920d2003 uy 0engur|n|---|||||txtccrSmall molecule DNA and RNA binders[electronic resource] from synthesis to nucleic acid complexes /M. Demeunynck, C. Bailly, W. D. Wilson (eds.)Weinheim Wiley-VCHc20031 online resource (756 p.)Description based upon print version of record.3-527-30595-5 Includes bibliographical references and index.Small Molecule DNA and RNA Binders; Contents; Preface; Contributors; 1 Forty Years On; 1.1 Early Experiments Prior to Molecular Modeling; 1.2 Formulation of Molecular Models and Mechanisms of Binding to DNA; 1.3 Specificity of Nucleotide Sequence Recognition; 1.4 Details at the Atomic and Molecular Levels; 1.5 Identification of Motifs for Drug Design; 1.6 Actions on Nucleoproteins, Chromatin, and Enzymes; References; 2 Targeting HIV RNA with Small Molecules; 2.1 Introduction; 2.1.1 Translation; 2.1.2 RNA Viruses; 2.2 Small Molecules that Modulate RNA Activity; 2.2.1 Magnesium (II)2.2.2 Aminoglycosides2.2.3 Ligand Specificity; 2.2.4 Goals; 2.3 The RRE and HIV Replication; 2.4 Determination of RRE-Ligand Affinity and Specificity; 2.4.1 Fluorescence Anisotropy; 2.4.2 Solid-phase (Affinity-Displacement) Assay; 2.4.3 Ethidium Bromide Displacement; 2.5 New RRE Ligands; 2.5.1 Neomycin-Acridine Conjugates; 2.5.2 Dimeric Aminoglycosides; 2.5.3 Guanidinoglycosides; 2.6 Conclusions; Acknowledgments; References; 3 RNA Targeting by Bleomycin; 3.1 Activation of Bleomycin for Polynucleotide Degradation; 3.2 Bleomycin-mediated Cleavage of Transfer RNAs and tRNA Precursor Transcripts4.6 Combinatorial Library Approach in the Discovery of Small Molecule Drugs Targeting RNA4.6.1 Combinatorial Chemistry; 4.6.2 Split Synthesis; 4.6.3 Encoding; 4.6.4 On-bead Screening and Identification of Structure-specific TAR-Binding Ligands; 4.6.5 Ligand Sequence Analysis; 4.6.6 Heterochiral Small Molecules Target TAR RNA Bulge; 4.6.7 Inhibition of Tat trans-Activation in vivo; 4.7 Cyclic Structures as RNA-targeting Drugs; 4.8 Summary and Perspective; Acknowledgments; References; 5 DNA and RNA Recognition and Modification by Gly-Gly-His-Derived Metallopeptides; 5.1 Introduction5.2.3.5 Guanine nucleobase modification/oxidationThe development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stDNA-drug interactionsMolecular biologyBinding sites (Biochemistry)Nucleic acidsDNA-drug interactions.Molecular biology.Binding sites (Biochemistry)Nucleic acids.572.8Demeunynck M(Martine)1605717Bailly Christian1605718Wilson W. D(W. David)1605719MiAaPQMiAaPQMiAaPQBOOK9910831076803321Small molecule DNA and RNA binders3931117UNINA