03830nam 2200649Ia 450 991083098960332120230721004059.01-282-34320-397866123432090-470-75403-60-470-75402-8(CKB)1000000000687497(EBL)470457(SSID)ssj0000290048(PQKBManifestationID)11220389(PQKBTitleCode)TC0000290048(PQKBWorkID)10402479(PQKB)10204308(MiAaPQ)EBC470457(OCoLC)264615289(EXLCZ)99100000000068749720071023d2008 uy 0engur|n|---|||||txtccrThe biology of extracellular molecular chaperones[electronic resource] /[editors, Derek J. Chadwick and Jamie Goode]Chichester John Wiley20081 online resource (245 p.)Novartis Foundation symposium ;291Published in association with the Novartis Foundation."Symposium on The biology of extracellular molecular chaperones, held at the Novartis Foundation, London, 5-7 June 2007" -- p. v.0-470-72333-5 Includes bibliographical references and index.The Biology of Extracellular Molecular Chaperones; Contents; Chair's introduction; 1962-2007: a cell stress odyssey; DISCUSSION; The chaperone function: meanings and myths; DISCUSSION; Systems biology of molecular chaperone networks; DISCUSSION; Unusual cellular disposition of the mitochondrial molecular chaperones Hsp60, Hsp70 and Hsp10; DISCUSSION; Cell surface molecular chaperones as endogenous modulators of the innate immune response; DISCUSSION; Cell stress proteins in extracellular fluids: friend or foe?; DISCUSSION; HSP60 speaks to the immune system in many voices; DISCUSSIONCell stress proteins: novel immunotherapeuticsDISCUSSION; General discussion; Cell stress proteins as modulators of bacteria-host interactions; DISCUSSION; Chaperonin 60 and macrophage activation; DISCUSSION; Hsp70: a chaperokine; DISCUSSION; Extracellular functions of thioredoxin; DISCUSSION; HSP27: an anti-inflammatory and immunomodulatory stress protein acting to dampen immune function; DISCUSSION; BiP, an anti-inflammatory ER protein, is a potential new therapy for the treatment of rheumatoid arthritis; DISCUSSION; Final discussion; Contributor Index; Subject IndexThe heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the cell. It is now known that this is a key mechanism enabling cells to survive a multitude of physical, chemical and biological stresses. Since the promulgation of the 'molecular chaperone' concept as a general cellular function to control the process of correct protein folding, a large number oNovartis Foundation symposium ;291.Extracellular matrix proteinsCongressesMolecular chaperonesCongressesExtracellular molecular chaperonesBiologyExtracellular matrix proteinsMolecular chaperones572.6612.01575Chadwick Derek91632Goode Jamie283336Novartis Foundation.MiAaPQMiAaPQMiAaPQBOOK9910830989603321The biology of extracellular molecular chaperones4111446UNINA