03583nam 2200577 450 991083092280332120230421050622.01-283-28129-597866132812961-118-15060-01-118-15059-7(CKB)2550000000060222(EBL)818801(OCoLC)757486965(SSID)ssj0000550638(PQKBManifestationID)11318748(PQKBTitleCode)TC0000550638(PQKBWorkID)10505845(PQKB)10520045(MiAaPQ)EBC818801(EXLCZ)99255000000006022220160815h19961996 uy 0engur|n|---|||||txtccrBayesian methods and ethics in a clinical trial design /edited by Joseph B. KadaneNew York :John Wiley & Sons, Inc.,1996.©19961 online resource (344 p.)Wiley Series in Probability and StatisticsDescription based upon print version of record.0-471-84680-5 Includes bibliographical references at the end of each chapters and indexes.Bayesian Methods and Ethics in a Clinical Trial Design; Contents; Preface; About the Authors; PART I MAJOR ISSUES; 1 Introduction; 2 Ethically Optimizing Clinical Trials; 3 Admissibility of Treatments; 4 Statistical Issues in the Analysis of Data Gathered in the New Designs; PART II TEST CASE: VERAPAMIL/NITROPRUSSIDE; 5 Introduction to the Verapamil/Nitroprusside Study; 6 The Mechanics of Conducting a Clinical Trial; 7 The Verapamil/Nitroprusside Study: Comments on ""The Mechanics of Conducting a Clinical Trial""; 8 Computational Aspects of the Verapamil/Nitroprusside Study; 9 Being an Expert10 Issues of Statistical Design11 Operational History and Procedural Feasibility; 12 Verapamil versus Nitroprusside: Results of the Clinical Trial I; 13 Verapamil versus Nitroprusside: Results of the Clinical Trial II; PART III OTHER ISSUES; 14 The Law of Clinical Testing with Human Subjects: Legal Implications of the New and Existing Methodologies; 15 Commentary I on ""The Law of Clinical Testing with Human Subjects""; 16 Commentary II on ""The Law of Clinical Testing with Human Subjects""; 17 Author's Response to Commentaries I and II18 Whether to Participate in a Clinical Trial: The Patient's ViewPART IV EPILOGUE; 19 Epilogue; NAME INDEX; SUBJECT INDEXHow to conduct clinical trials in an ethical and scientifically responsible mannerThis book presents a methodology for clinical trials that produces improved health outcomes for patients while obtaining sound and unambiguous scientific data. It centers around a real-world test case--involving a treatment for hypertension after open heart surgery--and explains how to use Bayesian methods to accommodate both ethical and scientific imperatives.The book grew out of the direct involvement in the project by a diverse group of experts in medicine, statistics, philosophy, and the law. Wiley series in probability and statistics.Clinical trialsMoral and ethical aspectsClinical trialsMoral and ethical aspects.519.542Kadane Joseph B.MiAaPQMiAaPQMiAaPQBOOK9910830922803321Bayesian methods and ethics in a clinical trial design4067278UNINA