05411nam 2200673Ia 450 991014427410332120170814180155.01-280-72349-197866107234923-527-60824-93-527-60826-5(CKB)1000000000376653(EBL)481392(OCoLC)609855273(SSID)ssj0000301765(PQKBManifestationID)11215509(PQKBTitleCode)TC0000301765(PQKBWorkID)10264696(PQKB)10796418(MiAaPQ)EBC481392(EXLCZ)99100000000037665320060118d2006 uy 0engur|n|---|||||txtccrLigand design for G protein-coupled receptors[electronic resource] /edited by Didier RognanWeinheim ;[Great Britain] Wiley20061 online resource (286 p.)Methods and principles in medicinal chemistry ;v. 30Description based upon print version of record.3-527-31284-6 Includes bibliographical references and index.Ligand Design for G Protein-coupled Receptors; Contents; Preface; A Personal Foreword; List of Contributors; 1 G Protein-coupled Receptors in the Human Genome; 1.1 Introduction; 1.2 The Adhesion Family; 1.3 The Secretin Family; 1.4 The Frizzled/Taste 2 Family; 1.4.1 The Frizzled Receptor Cluster; 1.4.2 The Taste 2 Receptor Cluster; 1.5 The Glutamate Family; 1.6 The Rhodopsin Family; 1.6.1 The Rhodopsin α-Group; 1.6.1.1 The Prostaglandin Receptor Cluster; 1.6.1.2 The Amine Receptor Cluster; 1.6.1.3 The Opsin Receptor Cluster; 1.6.1.4 The Melatonin Receptor Cluster1.6.1.5 The MECA Receptor Cluster1.6.1.6 Other Rhodopsin α-Receptors; 1.6.2 Rhodopsin β-Group; 1.6.3 Rhodopsin γ-Group; 1.6.3.1 The SOG Receptor Cluster; 1.6.3.2 The Melanocyte Concentrating Hormone Receptor Cluster; 1.6.3.3 The Chemokine Receptor Cluster; 1.6.3.4 Other Rhodopsin γ-Receptors; 1.6.4 The Rhodopsin δ-Group; 1.6.4.1 The MAS-related Receptor Cluster; 1.6.4.2 The Glycoprotein Receptor Cluster; 1.6.4.3 The Coagulation Factor Receptor Cluster; 1.6.4.4 The Purinergic Receptor Cluster; 1.6.4.5 The Olfactory Receptor Cluster; 1.6.4.6 Other Rhodopsin α-Receptors; 1.7 Other GPCRs1.8 Future PerspectiveReferences; 2 Why G Protein-coupled Receptors Databases are Needed; 2.1 Introduction; 2.2 A Non-exhaustive List of the GPCR Data Models; 2.3 Using the Central Dogma of Biology; 2.4 Using the Tree of Life; 2.5 Using a Chemogenomic Approach; 2.6 Conclusion; References; 3 A Novel Drug Screening Assay for G Protein-coupled Receptors; 3.1 Introduction; 3.1.1 History; 3.1.2 Nuclear Translocation of Endogenous GPCRs; 3.1.3 The MOCA Method; 3.2 The MOCA Strategy Demonstrated with the D1 Dopamine Receptor; 3.2.1 Development of the Assay3.2.2 Concentration-dependent Antagonist Blockade of Nuclear Transport3.2.3 Measurement of Receptor Cell Surface Expression: Antagonist Binding of Receptors at Cell Surface; 3.3 Development of Quantitative Methodology Suitable for High Throughput Analysis; 3.3.1 Nuclear Translocation of Orphan GPCRs; 3.4 Discussion of the MOCA Method; 3.5 Conclusion; References; 4 Importance of GPCR Dimerization for Function: The Case of the Class C GPCRs; 4.1 Introduction; 4.2 Class C GPCRs are Multidomain Proteins; 4.2.1 The VFT; 4.2.2 The CRD; 4.2.3 The HD; 4.2.4 C-Tail4.3 Class C GPCRs are Constitutive Dimers4.4 Agonists Activate Class C GPCRs by Stabilizing the Closed State of the VFT; 4.5 Dimeric Functioning of the Dimer of VFTs; 4.5.1 Agonist Stoichiometry: Symmetry or Asymmetry?; 4.6 The Heptahelical Domain, the Target of Positive and Negative Allosteric Modulators, Behaves in a Manner Similar to Rhodopsin-like Class A GPCRs; 4.7 Allosteric Coupling Between the Extracellular and Heptahelical Domains within the Dimer; 4.7.1 Molecular Determinants of the Coupling Between the VFT and the HD; 4.7.2 Cis- and Trans-activation Can Exist within Class C GPCRs4.8 Asymmetric Functioning of the HD DimerG protein-coupled receptors (GPCRs) are one of the most important target classes in pharmacology and are the target of many blockbuster drugs. Yet only with the recent elucidation of the rhodopsin structure have these receptors become amenable to a rational drug design.Based on recent examples from academia and the pharmaceutical industry, this book demonstrates how to apply the whole range of bioinformatics, chemoinformatics and molecular modeling tools to the rational design of novel drugs targeting GPCRs. Essential reading for medicinal chemists and drug designers working with this Methods and principles in medicinal chemistry ;v. 30.Ligands (Biochemistry)G proteinsDrugsDesignElectronic books.Ligands (Biochemistry)G proteins.DrugsDesign.541.2242615.19Rognan Didier505528MiAaPQMiAaPQMiAaPQBOOK9910144274103321Ligand design for G protein-coupled receptors1968231UNINA02345nam 2200433 450 991079442390332120230630002103.01-78914-363-29781789143638(electronic book)(CKB)4100000011883453(MiAaPQ)EBC6538944(Au-PeEL)EBL6538944(OCoLC)1246429230(EXLCZ)99410000001188345320220705d2021 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierBreathing an inspired history /Edgar WilliamsLondon, England :Reaktion Books, Limited,[2021]©20211 online resource (280 pages) illustrations1-78914-362-4 Includes bibliographical references and index.The breath of life -- Early beliefs -- Industry and revolution -- Miasma and bad air -- Laboured breathing -- Breathing high and low -- Breathing fast and slow: breathe in, breathe out -- Inspired breathing -- Last gasp.Our knowledge of breathing has shaped our social history and philosophical beliefs since prehistory. Breathing occupied a spiritual status for the ancients, while today it is central to the practice of many forms of meditation, like Yoga. Over time physicians, scientists, and engineers have pieced together the intricate biological mechanisms of breathing to devise ever more sophisticated devices to support and maintain breathing indefinitely, from iron lungs to the modern ventilator. Breathing supplementary oxygen has allowed us to conquer Everest, travel to the Moon, and dive to ever greater ocean depths. We all expect to breathe fresh and clean air, but with an increase in air pollution that expectation is no longer being met. Today, respiratory viruses like COVID-19 are causing disasters both human and economical on a global scale. This is the story of breathing—a tale relevant to everyone.RespirationPopular worksRespiration613.192Williams Edgar Mark1960-1526006MiAaPQMiAaPQMiAaPQBOOK9910794423903321Breathing3767796UNINA03943nam 2200589Ia 450 991083091550332120230422045519.01-282-68159-197866126815923-527-62438-43-527-62439-2(CKB)1000000000577930(EBL)481973(OCoLC)299047765(SSID)ssj0000333846(PQKBManifestationID)11266769(PQKBTitleCode)TC0000333846(PQKBWorkID)10377575(PQKB)11409521(MiAaPQ)EBC481973(EXLCZ)99100000000057793019961119d1999 uy 0gerur|n|---|||||txtccrAbluft und abgas[electronic resource] reinigung und überwachung /Norbert EbelingWeinheim VCHc19991 online resource (253 p.)Includes index.3-527-29621-2 Abluft und Abgas; Inhalt; 1 Grundlagen; 1.1 Die Luft als Teil des menschlichen Lebensraumes; 1.2 Gesetzeslage und Grenzwerte; 1.3 Interpretation und Anwendung von Vorschriften; 1.4 Literatur; 2 Abscheidung von Feststoffen; 2.1 Staubquellen; 2.2 Entstaubungstechnik; 2.2.1 Entstaubung durch Sedimentation; 2.2.2 Fliehkraftentstauber oder Zyklone; 2.2.3 Filternde Abscheider; 2.2.4 Elektroentstauber; 2.2.5 Waschentstauber; 2.2.6 Betriebssicherheit von Entstaubern; 2.3 Technisch-wirtschaftlicher Verfahrensvergleich; 2.4 Literatur; 3 Abscheidung von Flüssigkeiten; 3.1 Tröpfchenbildung3.2 Abscheider3.3 Literatur; 4 Abscheidung gasförmiger Schadstoffe; 4.1 Absorption; 4.1.1 Gaswäscherbauarten und ihre Berechnung; 4.1.2 Rauchgasentschwefelung; 4.1.3 Absorber für Rückstandsverbrennungsanlagen; 4.2 Adsorption; 4.2.1 Physikalische Grundlagen; 4.2.2 Adsorptionsmittel; 4.2.3 Adsorberbauarten im Vergleich; 4.3 Katalytische Abgasreinigung; 4.3.1 Grundlagen; 4.3.2 Rauchgasentstickung; 4.3.3 Dreiwegekatalysatoren für motorische Zwecke; 4.4 Thermische und katalytische Nachverbrennung; 4.5 Direktverfahren; 4.6 Biologische Verfahren; 4.7 Zusammenfassung und Ratgeber; 4.8 Literatur5 Nichtstoffliche Emissionen5.1 Schallschutz; 5.2 Störende Lichtemissionen; 5.3 Elektrosmog; 5.4 Strahlenschutz; 5.5 Literatur; 6 Emissionsüberwachung; 6.1 Gesetzliche und theoretische Grundlagen; 6.2 Methoden und Anwendungen; 6.3 Literatur; 7 Der systematische Weg von der Problemstellung zur technischen Lösung; 7.1 Allgemeiner Ratgeber; 7.2 Ablaufdiagramme; 7.3 Arbeitsanweisungen und Checklisten; 7.4 Literatur; Anhang 1; A 1.1 Behördenanschriften; A 1.2 Anschriften anerkannter Meßinstitute; Anhang 2; Bezugsquellen juristischer und technischer Vorschriften; Anhang 3Nachschlagewerke und weiterführende LiteraturRegisterAlle Bände der Reihe ""Praxis des technischen Umweltschutzes"" bieten eine kompakte Einführung und Übersicht zu diesem Thema. Erfahren Sie hier, welche Verfahren es zur Vermeidung und Verminderung von Emissionen gibt und wie sich umweltgesetzliche Vorschriften einhalten lassen. Außerdem wird die Einbindung des technischen Umweltschutzes in das Umweltmanagement behandelt.Dieser Band ist ein praktischer Leitfaden für die Reinigung und Überwachung von Abluft und Abgas. Der Anwender findet mit ihm vom Problem zur technischen Lösung, insbesondere durch die als ""Entscheidungsbäume"" gestaltAir quality managementAirPollutionAir quality management.AirPollution.628.53628.5308697.93Ebeling Norbert1342762MiAaPQMiAaPQMiAaPQBOOK9910830915503321Abluft und abgas3066490UNINA