01924nam 2200445 a 450 991070186300332120120911151115.0(CKB)5470000002421477(OCoLC)794596616(EXLCZ)99547000000242147720120601d2012 ua 0engurbn||||a||||txtrdacontentcrdamediacrrdacarrierBioterrorism, controlled substances, and public health issues[electronic resource] hearing before the Subcommittee on Health of the Committee on Energy and Commerce, House of Representatives, One Hundred Twelfth Congress, first session, July 21, 2011Washington :U.S. G.P.O.,2012.1 online resource (iv, 150 pages)Title from title screen (viewed on June 1, 2012).Paper version available for sale by the Supt. of Docs., U.S. G.P.O."Serial no. 112-79."Includes bibliographical references.Bioterrorism, controlled substances, and public health issues Emergency managementLaw and legislationUnited StatesEmergency medical servicesLaw and legislationUnited StatesHealth planningLaw and legislationUnited StatesDesigner drugsLaw and legislationUnited StatesMedicineResearchLaw and legislationUnited StatesEmergency managementLaw and legislationEmergency medical servicesLaw and legislationHealth planningLaw and legislationDesigner drugsLaw and legislationMedicineResearchLaw and legislationGPOGPOBOOK9910701863003321Bioterrorism, controlled substances, and public health issues3519678UNINA05046nam 22006134a 450 991083088260332120230617021328.01-280-52041-897866105204113-527-60532-03-527-60153-8(CKB)1000000000019320(EBL)482385(OCoLC)68907055(SSID)ssj0000119181(PQKBManifestationID)11134330(PQKBTitleCode)TC0000119181(PQKBWorkID)10055958(PQKB)10688941(MiAaPQ)EBC482385(EXLCZ)99100000000001932020030814d2003 uy 0engur|n|---|||||txtccrCell membrane[electronic resource] the red blood cell as a model /Yoshihito YawataWeinheim Wiley-VCHc20031 online resource (457 p.)Description based upon print version of record.3-527-30463-0 Includes bibliographical references and index.Cell Membrane; Contents; Preface; Foreword; Acknowledgments; 1 Introduction: History of Red Cell Membrane Research; 1.1 Invention of Optical Microscopes and Their Application to Hematology; 1.2 Discovery of Hereditary Spherocytosis by Light Microscopy; 1.3 The Dawn of Red Cell Membrane Research; 1.4 Commencement of Membrane Protein Biochemistry: Introduction of Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis; 1.5 Elucidation of the Pathogenesis of Red Cell Membrane Disorders; 1.6 Genotypes of Red Cell Membrane Disorders1.7 Reevaluation of Molecular Electron Microscopy for Phenotypes2 Composition of Normal Red Cell Membranes; 2.1 Introduction; 2.2 Membrane Lipids; 2.2.1 The Contents and Nature of Membrane Lipids; 2.2.2 Asymmetry of the Membrane Lipid Bilayer; 2.2.3 Membrane Fluidity; 2.2.4 Renewal of Membrane Lipids; 2.2.5 Interactions Between Membrane Lipids and Proteins; 2.2.6 Membrane Lipids as a Determinant of Red Cell Shape; 2.3 Membrane Proteins; 2.3.1 Separation and Identification of Membrane Proteins; 2.3.2 Membrane Proteins and Membrane Structure; 2.3.3 Membrane Proteins in the Red Cell Surface2.3.4 Membrane Proteins and Membrane Functions2.3.4.1 Red Cell Morphology and Shape Change; 2.3.4.2 Red Cell Deformability; 2.3.4.3 Membrane Transport and Permeability; 3 Stereotactic Structure of Red Cell Membranes; 3.1 Historical Background to Membrane Models; 3.2 Ultrastructure of Red Cell Membranes; 3.2.1 Introduction; 3.2.2 Evaluation of the Cytoskeletal Network; 3.2.2.1 Electron Microscopy With the Negative Staining Method; 3.2.2.2 Electron Microscopy With the Quick-Freeze Deep-Etching (QFDE) Method; 3.2.2.3 Electron Microscopy With the Surface Replica (SR) Method3.2.3 Integral Proteins Examined by Electron Microscopy With the Freeze Fracture Method3.2.4 Visualization of Glycophorins by Field Emission Scanning Electron Microscopy; 4 Skeletal Proteins; 4.1 α- and β-Spectrins; 4.1.1 Introduction; 4.1.2 Structure of Red Cell Spectrins; 4.1.3 Functions of Red Cell Spectrins; 4.1.4 Erythroid and Nonerythroid Spectrins; 4.2 Protein 4.1; 4.2.1 Structure of Protein 4.1; 4.2.2 Binding to Other Membrane Proteins; 4.2.3 Extensive Alternative Splicings; 4.2.4 Nonerythroid Protein 4.1 Isoforms; 4.3 Actin; 4.4 Other Minor Skeletal Proteins; 4.4.1 The p55 Protein4.4.2 Adducin4.4.3 Dematin (Protein 4.9); 4.4.4 Tropomyosin; 4.4.5 Tropomodulin; 4.4.6 Other Membrane Proteins; 5 Integral Proteins; 5.1 Band 3; 5.1.1 Structure of Band 3; 5.1.2 Functions of Band 3; 5.1.2.1 Membrane Protein Binding by the Cytoplasmic Domain of Band 3; 5.1.2.2 Binding to Glycolytic Enzymes by the Cytoplasmic Domain of Band 3; 5.1.2.3 Binding to Hemoglobin by the Cytoplasmic Domain of Band 3; 5.1.2.4 Anion Exchange Channel by the Transmembrane Domain of Band 3; 5.1.2.5 Lateral and Rotational Mobility of Band 3; 5.1.2.6 Blood Type Antigens and Band 35.1.3 Band 3 in Nonerythyroid CellsThis publication presents the structure and function of biological membranes to improve the understanding of cells in both normal and pathogenic states. Recently, vast amounts of new information have been accumulated, especially about pathological conditions, and there is now much evidence correlating genotypes and phenotypes in normal and disease states. This book surveys the most recent findings in research on the molecular biology, biochemistry, and genetics of the membranes of human red blood cells.Erythrocyte membranesMembrane proteinsErythrocyte membranes.Membrane proteins.612.111616.0792Yawata Yoshihito1936-1670034MiAaPQMiAaPQMiAaPQBOOK9910830882603321Cell membrane4031611UNINA