03750nam 22006374a 450 991083086240332120170810183550.01-280-23859-397866102385900-470-02052-00-470-02051-2(CKB)1000000000356165(EBL)239005(SSID)ssj0000114281(PQKBManifestationID)11143086(PQKBTitleCode)TC0000114281(PQKBWorkID)10102281(PQKB)11686337(MiAaPQ)EBC239005(OCoLC)85820824(PPN)137624662(EXLCZ)99100000000035616520030925d2004 uy 0engur|n|---|||||txtccrBrain energetics and neuronal activity[electronic resource] applications to fMRI and medicine /editors, R.G. Shulman and D.L. RothmanChichester, West Sussex, England ;Hoboken, N.J. J. Wileyc20041 online resource (335 p.)Description based upon print version of record.0-470-84720-4 Includes bibliographical references and index.Brain Energetics and Neuronal Activity; Contents; Contributors; Foreword; Section A: Background; 1 Introduction; 2 Energy Metabolism in Neural Tissues in vivo at Rest and in Functionally Altered States; 3 Techniques-MRS, fMRI, (13)C NMR, Indirect Detection of (13)C; 4 Metabolic Modeling Analysis of Brain Metabolism; Section B: Neuroenergetics and Activity; 5 Cerebral Energetics and Neurotransmitter Fluxes; 6 NMR Studies of the Metabolism and Energetics of GABA Neurotransmitter Pathways; 7 Neural Energy Consumption and the Representation of Mental Events8 Imaging Cerebral Metabolic Rate of Oxygen Consumption (CMRO(2)) using (17)O NMR Approach at Ultrahigh Field9 Deriving Changes in CMR(O2) from Calibrated fMRI; 10 Relationship between CMR(O2) and Neuronal Activity; Section C: Clinical Beginnings; 11 NMR Studies of Bioenergetic Impairment in Human Epilepsy; 12 MRS Studies of the Role of Altered Glutamate and GABA Neurotransmitter Metabolism in the Pathophysiology of Epilepsy; 13 The Role of Altered Energetics of Neurotransmitter Systems in Psychiatric Disease; Section D: Brain and Mind14 Long-term Memory: Do Incremental Signals Reflect Engagement of Cognitive Processes?15 Using fMRI to Study the Mind and Brain; 16 Brain and Mind: an NMR Perspective; 17 The Role of the NMR Baseline Signal in the Study of Consciousness: the Restless Brain; IndexThis book is unique in linking in vivo 13C NMR measurements of neuronal activity and energetics with applications to functional imaging and certain disease states It provides a fundamental neurochemical explanation of brain activity applicable to functional imaging, theories of neuronal activity and disease states, e.g. epilepsy, psychiatric diseases and developmental disorders.Novel and potentially controversialWill inspire future research directionsBrainMetabolismEnergy metabolismBrainPathophysiologyBrainMagnetic resonance imagingBrainMetabolism.Energy metabolism.BrainPathophysiology.BrainMagnetic resonance imaging.612.82Shulman R. G(Robert Gerson)1611280Rothman D. L(Douglas L.)1611281MiAaPQMiAaPQMiAaPQBOOK9910830862403321Brain energetics and neuronal activity4049959UNINA