03477nam 22006134a 450 991083083590332120230721003732.01-281-83126-397866118312640-470-39927-90-470-39926-0(CKB)1000000000557011(EBL)362114(OCoLC)476191902(SSID)ssj0000218737(PQKBManifestationID)11175958(PQKBTitleCode)TC0000218737(PQKBWorkID)10221130(PQKB)10279419(MiAaPQ)EBC362114(EXLCZ)99100000000055701120080403d2008 uy 0engur|n|---|||||txtccrPathway analysis for drug discovery[electronic resource] computational infrastructure and applications /edited by Anton YuryevHoboken, N.J. John Wiley & Sonsc20081 online resource (332 p.)Wiley series on technologies for the pharmaceutical industryDescription based upon print version of record.0-470-10705-7 Includes bibliographical references and index.PATHWAY ANALYSIS FOR DRUG DISCOVERY; CONTENTS; Preface; Contributors; 1 Introduction to Pathway Analysis; 2 Software Infrastructure and Data Model for Pathway Analysis; 3 Automatic Pathway Inference in Heterogeneous Biological Association Networks; 4 Algorithmic Basis for Pathway Visualization; 5 Pathway Analysis of High-Throughput Experimental Data; 6 Integrative Pathway Analysis of Disease Molecular Data; 7 Whole-Genome Expression Profiling of Papillary Serous Ovarian Cancer: Activated Pathways, Potential Targets, and Noise; 8 Mammalian Proteome and Toxicant Network Analysis9 Unraveling Mechanisms of Toxicity with the Power of Pathways: ToxWiz Tool as an Illustrative Example10 Impact of Chemistry Information on Pathway Analysis; 11 Propagation of Concentration Perturbations in Equilibrium Protein Binding Networks; 12 An Adaptive System Model of the Yeast Glucose Sensor System; 13 Present and Future of Pathway Analysis in Drug Discovery; IndexThis book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in relaWiley series on technologies for the pharmaceutical industry.Drug developmentData processingDNA microarraysData processingComputational biologyDrug developmentData processing.DNA microarraysData processing.Computational biology.615.19615/.190285Yuryev Anton1627913MiAaPQMiAaPQMiAaPQBOOK9910830835903321Pathway analysis for drug discovery3964741UNINA