02650nam 22006134a 450 991083083440332120230721032540.01-281-38145-497866113814550-470-28189-80-470-28187-1(CKB)1000000000535839(EBL)353409(OCoLC)476174736(SSID)ssj0000112224(PQKBManifestationID)11819492(PQKBTitleCode)TC0000112224(PQKBWorkID)10087746(PQKB)11538174(MiAaPQ)EBC353409(EXLCZ)99100000000053583920071026d2008 uy 0engur|n|---|||||txtccrBioorganic and medicinal chemistry of fluorine[electronic resource] /Jean-Pierre Bégué, Danièle Bonnet-Delpon ; translated from French by Julien LegrosHoboken, N.J. John Wiley & Sonsc20081 online resource (385 p.)Translated from the French.0-470-27830-7 Includes bibliographic references and index.General remarks on structural, physical, and chemical properties of fluorinated compounds -- Overview on the preparation of fluorinated compounds -- Effects of fluorine substitution on biological properties -- Fluorinated analogues of natural products -- Fluorinated derivatives of ?-amino acids and proteins -- Saccharidic fluorinated derivatives -- Inhibition of enzymes by fluorinated compounds -- Fluorinated drugs. Provides a thorough overview of the role of fluorine in pharmaceutical science and development Includes chapters on fluorinated analogues of natural products, fluorinated amino acids and peptides, and derivatives of sugars Classifies marketed and in-development fluorinated pharmaceuticals according to their therapeutic classesFluorine compoundsTherapeutic useFluorinePhysiological effectOrganofluorine compoundsBioorganic chemistryFluorine compoundsTherapeutic use.FluorinePhysiological effect.Organofluorine compounds.Bioorganic chemistry.547.02547/.02Bégué Jean-Pierre1627905Bonnet-Delpon Danièle1627906MiAaPQMiAaPQMiAaPQBOOK9910830834403321Bioorganic and medicinal chemistry of fluorine3964727UNINA