04392nam 2200553 450 991083057220332120170919191939.03-527-67714-33-527-67713-53-527-67712-7(CKB)4330000000010553(EBL)4558130(MiAaPQ)EBC4558130(PPN)226378454(EXLCZ)99433000000001055320160711h20162016 uy 0engur|n|---|||||rdacontentrdamediardacarrierApplied biocatalysis from fundamental science to industrial applications /edited by Lutz Hilterhaus [and three others]Weinheim, Germany :Wiley-VCH Verlag GmbH & Co. KGaA,2016.©20161 online resource (464 p.)Description based upon print version of record.3-527-33669-9 Includes bibliographical references at the end of each chapters and index.Cover; Title Page; Copyright; Contents; List of Contributors; Preface; Part A Molecular Biology, Enzyme Screening and Bioinformatics; Part B Biocatalytic Synthesis; Part C Reaction and Process Engineering; Index; EULA; Chapter 1 Engineering Lipases with an Expanded Genetic Code; Chapter 2 Screening of Enzymes: Novel Screening Technologies to Exploit Noncultivated Microbes for Biotechnology; Chapter 3 Robust Biocatalysts - Routes to New Diversity; Chapter 4 Application of High-Throughput Screening in Biocatalysis; Chapter 5 Supporting Biocatalysis Research with Structural BioinformaticsChapter 6 Engineering Proteases for Industrial ApplicationsChapter 7 Biocatalytic Synthesis of Natural Products by O-Methyltransferases; Chapter 8 Biocatalytic Phosphorylation of Metabolites; Chapter 9 Flavonoid Biotechnology - New Ways to High-Added-Value Compounds; Chapter 10 Transaminases - A Biosynthetic Route for Chiral Amines; Chapter 11 Biocatalytic Processes for the Synthesis of Chiral Alcohols; Chapter 12 Inorganic Adsorbents in Enzymatic Processes; Chapter 13 Industrial Application of Membrane Chromatography for the Purification of EnzymesChapter 14 Fermentation of Lactic Acid Bacteria: State of the Art and New PerspectivesChapter 15 The Bubble Column Reactor: A Novel Reactor Type for Cosmetic Esters; Chapter 16 Pharmaceutical Intermediates by Biocatalysis: From Fundamental Science to Industrial Applications; Chapter 17 Biocatalysis toward New Biobased Building Blocks for Polymeric Materials; 1.1 Introduction; 1.2 Enzyme Activity of Lipases from Different Sources and Engineering Approaches; 1.3 Noncanonical Amino Acids in Lipase Design and Engineering1.4 Case Study: Manipulating Proline, Phenylalanine, and Methionine Residues in Lipase1.5 ""Unnatural"" Lipases Are Able to Catalyze Reactions under Different Hostile Environments; 1.6 Lipase Engineering via Bioorthogonal Chemistries: Activity and Immobilization; 1.7 Conclusions and Perspectives; References; 2.1 Introduction; 2.2 Sequence- versus Function-Based Metagenomic Approach to Find Novel Biocatalysts; 2.3 Alternative Hosts, Metatranscriptomics, and Metaproteomics; 2.4 Future Perspectives; References; 3.1 Introduction3.2 Metagenomics to Retrieve New Genes from Extremophilic Microorganisms3.3 Microbial Expression Hosts for the Production of Extremozymes; 3.4 Molecular Biology Approaches for Enzyme Improvement; 3.5 Conclusions and Future Perspectives; References; 4.1 Introduction; 4.2 Discussions; 4.3 Summary; References; 5.1 Introduction; 5.2 Computational Tools to Assist Biocatalysis Research; 5.3 From Active Site Analysis to Protein Stability Considerations; 5.4 Applying DoGSiteScorer and HYDE to Biocatalytical Questions; 5.5 Conclusion and Future Directions; Acknowledgments; References6.1 Proteases in IndustryEnzymesBiotechnologyBiocatalysisEnzymesIndustrial applicationsEnzymesBiotechnology.Biocatalysis.EnzymesIndustrial applications.660.634Hilterhaus LutzMiAaPQMiAaPQMiAaPQBOOK9910830572203321Applied biocatalysis4085322UNINA