05306nam 2200685 450 991083053760332120230109121004.01-119-99864-61-118-29962-01-119-97988-91-283-27287-397866132728740-470-09005-7(CKB)2550000000054253(EBL)818609(OCoLC)764650212(SSID)ssj0000537814(PQKBManifestationID)11324391(PQKBTitleCode)TC0000537814(PQKBWorkID)10554520(PQKB)10802845(MiAaPQ)EBC818609(MiAaPQ)EBC7076277(Au-PeEL)EBL7076277(PPN)250328437(EXLCZ)99255000000005425320230109d2012 uy 0engur|n|---|||||txtccrImmunology mucosal and body surface defences /Andy E. Williams, with contributions from Tracy Hussell, Clare Lloyd2nd ed.Chichester, England ;Hoboken, New Jersey :Wiley-Blackwell,[2012]©20121 online resource (400 p.)Includes index.0-470-09003-0 0-470-09004-9 Immunology; Contents; Preface; List of Standard Cells and Symbols; 1 Basic Concepts in Immunology; 1.1 The immune system; 1.2 Tissues and cells of the immune system; 1.3 Activation, regulation and functions of immune responses; 1.4 Innate versus adaptive immunity; 1.5 Primary and secondary immune responses; 1.6 Immune cell development; 1.7 Mast cells and basophils; 1.8 Eosinophils; 1.9 Neutrophils; 1.10 Monocytes and macrophages; 1.11 Dendritic cells; 1.12 Natural killer cells; 1.13 CD4+ T helper cells; 1.14 CD8+ cytotoxic T cells; 1.15 B cells; 1.16 gd T cells; 1.17 Natural killer T cells1.18 Anatomy of the immune system1.19 Lymph nodes; 1.20 Spleen; 1.21 Summary; 2 The Innate Immune System; 2.1 Introduction to the innate immune system; 2.2 Innate immune receptors and cells; 2.3 TLRs and pattern recognition; 2.4 TLR signalling in response to LPS; 2.5 Peptidoglycan and Nods; 2.6 Nod-like receptors recognize PAMPs and DAMPs; 2.7 Damage associated molecular patterns (DAMPs); 2.8 Complement proteins perform several innate immune functions; 2.9 The classical complement pathway; 2.10 The lectin and alternative complement pathways2.11 Biological properties of complement cleavage products2.12 Opsonization by complement proteins; 2.13 Phagocytosis; 2.14 Fc receptors induce phagocytosis; 2.15 Neutrophil function and the respiratory burst; 2.16 ADCC; 2.17 NK cells recognize missing self; 2.18 Activating adaptive immunity; 2.19 Dendritic cells link innate and adaptive immunity; 2.20 Summary; 3 The Adaptive Immune System; 3.1 Introduction to adaptive immunity; 3.2 T cells and B cells recognize foreign antigens; 3.3 Overview of antibody structure; 3.4 Constant region and antibody isotypes; 3.5 B cell receptor (BCR) diversity3.6 Genetic recombination of BCR genes3.7 Mechanism of VDJ recombination; 3.8 Introducing junctional diversity; 3.9 Somatic hypermutation and affinity maturation; 3.10 Immunoglobulin class switching; 3.11 Structure of Fc receptors; 3.12 Fc receptor specificity and affinity; 3.13 Cross-linking of antibody is necessary for Fc receptor signalling; 3.14 Fc receptor immune functions; 3.15 T cell receptor diversification; 3.16 T cells undergo positive and negative selection within the thymus; 3.17 Antigen presentation to T cells; 3.18 MHC class II processing pathway3.19 MHC class I processing pathway3.20 Activation requires co-stimulation; 3.21 Late co-stimulatory signals; 3.22 Activation of B cell responses; 3.23 CD4+ T helper cell differentiation; 3.24 Activation of CTLs; 3.25 Generation of memory T cells; 3.26 Summary; 4 Cytokines; 4.1 Introduction to cytokines; 4.2 Structure of cytokine families; 4.3 IL-1 superfamily; 4.4 IL-6 family; 4.5 IL-10 family; 4.6 Common g-chain family; 4.7 IL-12 family; 4.8 Interferons; 4.9 TNF ligand superfamily; 4.10 Growth factors; 4.11 Functional classification Th1 versus Th24.12 Th17, immunopathology and regulatory cytokines2012 PROSE Award, Clinical Medicine: Honorable MentionThe vast majority of medically important pathogens infect their host across a body surface such as the skin, or across a mucosal tissue such as the respiratory tract or intestines, as these sites are the ones exposed to the external environment. By focusing on immunity at mucosal and body surfaces this book presents a fresh, new approach to the teaching of immunology. After an introduction to the basic structure of the immune system, the book looks at two important families of signalling molecules: cytokines and chemokiImmunologyTextbooksImmunology616.079Williams Andrew1975-1666578Hussell TracyLloyd Clare(Clare M.),MiAaPQMiAaPQMiAaPQBOOK9910830537603321Immunology4025898UNINA