03393nam 22006494a 450 991083053190332120230617005800.01-280-27251-197866102725180-470-66753-20-470-86997-60-470-86999-2(CKB)1000000000356010(EBL)232716(SSID)ssj0000112065(PQKBManifestationID)11137879(PQKBTitleCode)TC0000112065(PQKBWorkID)10081583(PQKB)10213077(MiAaPQ)EBC232716(OCoLC)85820915(EXLCZ)99100000000035601020040701d2004 uy 0engur|n|---|||||txtccrBiology of IGF-1[electronic resource] its interaction with insulin in health and malignant states /[edited by Gregory Bock, Jamie Goode]The Atrium, Southern Gate, Chichester, UK ;Hoboken, NJ John Wiley & Sonsc20041 online resource (294 p.)Novartis Foundation symposium ;262Description based upon print version of record.0-470-86998-4 Includes bibliographical references and indexes.Circulating IGF-I and its role in cancer: lessons from the IGF-1 gene-deletion (LID) mouse -- Physiology of the IGF system -- Molecular basis of insulin action -- IGF-1 and insulin as growth hormones -- Insulin-like growth factors and neoplasia -- Loss of IGF2 imprinting: mechanisms and consequences -- Insulin and IGF-1 receptor trafficking and signalling -- The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb -- Structural biology of insulin and IGF-1 receptors -- Genetic blockade of the insulin-like growth factor-I receptor for human malignancy -- IGF-1 and prostate cancer -- IGF-1 and breast cancer -- IGFBPs and cancer -- The IGF receptor as anticancer treatment target -- Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence.An invaluable book containing a series of interdisciplinary discussions between clinical and basic scientists. Biology of IGF-1: Its interaction with insulin and health and malignant states focuses on key issues such as:the definition of danger zonesthe development of methods for early recognition of malignant states linked to IGF-1 and/or insulinpossible approaches to preventative interventionthe relevance in this field of research to the development of novel therapeutic approaches to treating certain cancers.Novartis Foundation symposium ;262.SomatomedinPhysiological effectCongressesSomatomedinPathophysiologyCongressesCarcinogenesisCongressesSomatomedinPhysiological effectSomatomedinPathophysiologyCarcinogenesis612.01575612/.01575644.78bclBock Gregory322650Goode Jamie283336Symposium on Biology of IGF-1MiAaPQMiAaPQMiAaPQBOOK9910830531903321Biology of IGF-14025856UNINA