03854nam 22006254a 450 991083029840332120230828225733.01-280-51891-X97866105189130-470-02957-90-470-02956-0(CKB)1000000000357348(EBL)267158(SSID)ssj0000148787(PQKBManifestationID)11147020(PQKBTitleCode)TC0000148787(PQKBWorkID)10225175(PQKB)11243726(MiAaPQ)EBC267158(OCoLC)85784250(EXLCZ)99100000000035734820070403d2006 uy 0engur|n|---|||||txtccrEpithelial anion transport in health and disease[electronic resource] the role of the SLC26 transporters familyChichester, U.K. John Wiley & Sons20061 online resource (285 p.)Novartis Foundation Symposium ;273Description based upon print version of record.0-470-01624-8 Includes bibliographical references and index.Cover; Contents; Chair's introduction; Overview of the SLC26 family and associated diseases; Discussion; Individual characteristics of members of the SLC26 family in vertebrates and their homologues in insects; Discussion; Sulfate transport by SLC26 transporters; Discussion; Sugar transport by members of the SLC26 superfamily; Discussion; SLC26A3 and congenital chloride diarrhoea; Discussion; Expression, regulation and the role of SLC26 C1/HCO exchangers in kidney and gastrointestinal tract; DiscussionAnion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptidesDiscussion; Physiology of electrogenic SLC26 paralogues; Discussion; Role of SLC26-mediated C1/base exchange in proximal tubule NaCl transport; Discussion; SLC26 transporters and the inhibitory control of pancreatic ductal bicarbonate secretion; Discussion; Regulatory interaction between CFTR and the SLC26 transporters; Discussion; Insights from a transgenic mouse model on the role of SLC26A2 in health and disease; DiscussionNew insights into the role of pendrin (SLC26A4) in inner ear fluid homeostasisDiscussion; The renal physiology of pendrin (SLC26A4) and its role in hypertension; Discussion; Interaction of prestin (SLC26A5) with monovalent intracellular anions; Discussion; Final discussion; Index of contributors; Subject indexCl- absorption and HCO3- secretion are intimately associated processes vital to epithelial function, itself a key physiological activity. Until recently the transporters responsible remained obscure, but a breakthrough occurred with the discovery of the SLC26 transporters family. It is now clear that the SLC26 transporters have broad physiological functions since mutations in several members are linked to a variety of diseases. This book describes the properties of this family in detail, with contributions from the leading global researchers in the field. Complementary views from experts on otNovartis Foundation symposium ;273.Epithelial cellsCongressesCarrier proteinsCongressesIon channelsCongressesEpithelial cellsCarrier proteinsIon channels571.55364616.042Symposium on Epithelial Anion Transport in Health and Disease: the Role of the SLC26 Transporters FamilyMiAaPQMiAaPQMiAaPQBOOK9910830298403321Epithelial anion transport in health and disease3943496UNINA