05367nam 2200673Ia 450 991083021630332120170809162357.01-282-30246-997866123024663-527-62742-13-527-62743-X(CKB)1000000000799327(EBL)481415(SSID)ssj0000343908(PQKBManifestationID)11250996(PQKBTitleCode)TC0000343908(PQKBWorkID)10292175(PQKB)10412674(MiAaPQ)EBC481415(OCoLC)587390742(PPN)163569479(EXLCZ)99100000000079932720090429d2009 uy 0engur|n|---|||||txtccrTransporters as drug carriers[electronic resource] structure, function, substrates /edited by Gerhard Ecker and Peter ChibaWeinheim Wiley-VCHc20091 online resource (451 p.)Methods and principles in medicinal chemistry ;v. 44Description based upon print version of record.3-527-31661-2 Includes bibliographical references and index.Transporters as Drug Carriers: Structure, Function, Substrates; Contents; List of Contributors; Preface; A Personal Foreword; Part One: Human Transporter Families - Structure, Function, Physiology; 1 The ABC Transporters: Structural Insights into Drug Transport; 1.1 ABC Proteins - Structure and Function; 1.1.1 ABC Proteins; 1.1.2 Predicted Topology of ABC Proteins; 1.1.3 Nucleotide Binding Domains; 1.1.3.1 Conserved Motifs of NBDs; 1.1.4 Transmembrane Domains; 1.1.5 Mechanisms of Transport; 1.1.6 Energy for Translocation; 1.1.7 Coupling of ATP Hydrolysis to Transport1.2 Structures of ABC Transporters1.2.1 Tertiary Structure; 1.2.2 Quaternary Structure of ABC Proteins; 1.3 Multidrug Resistance and ABC Transporters; 1.3.1 P-Glycoprotein; 1.3.1.1 Historical Background; 1.3.1.2 The Role of P-gp in Drug Resistance; 1.3.1.3 Tissue Distribution and Physiological Roles; 1.3.2 Conformational Changes in the Mechanism of P-gp; 1.3.3 Comparison of Sav1866 and P-gp Structures; 1.3.4 Drug Binding Sites in P-Glycoprotein; 1.3.5 Structural Interpretation of Drug Binding; 1.3.6 Inhibitors of P-gp1.3.7 What Properties Are Shared by Drugs that Interact with P-Glycoprotein?1.3.8 Postscript: Further X-Ray Crystallographic Studies and a Structure for the Nucleotide-Free State of P-Glycoprotein; 1.4 Summary; References; 2 Biochemistry, Physiology, and Pharmacology of Nucleoside and Nucleobase Transporters; 2.1 Nucleoside and Nucleobase Transporters; 2.1.1 Equilibrative Nucleoside Transporters; 2.1.2 Concentrative Nucleoside Transporters; 2.2 ENT and CNT Tissue Distribution, Regulation, and Physiological Roles; 2.2.1 ENT Tissue Distribution and Regulation2.2.2 CNT Tissue Distribution and Regulation2.2.2.1 CNTs in Absorptive Epithelia; 2.2.2.2 CNTs in Liver Parenchymal Cells; 2.2.2.3 CNTs in Immune System Cells; 2.2.2.4 CNTs in CNS; 2.2.2.5 CNTs in Other Specialized Tissues; 2.2.3 NTs as ""Transceptors""; 2.3 Nucleoside- and Nucleobase-Derived Drug Transport into Cells; 2.3.1 Transport of Anticancer Drugs; 2.3.2 Transport of Antiviral Drugs; 2.4 Drug Transport and Responsiveness to Treatment; 2.4.1 Analysis of the Role of NTs in Sensitivity to Nucleoside Anticancer Drugs in Cultured Cell Models2.4.2 Studies Linking NT Function to Drug Sensitivity and Clinical Outcome in Cancer Patients2.5 Future Perspectives; References; 3 Organic Anion Transporting Polypeptides (Oatps/OATPs); 3.1 Introduction; 3.2 Nomenclature and Classification; 3.3 Tissue Distribution, Structure, and Functions; 3.4 Substrate Spectrum; 3.5 Members of the Rodent Oatp Family; 3.5.1 Oatp1a1; 3.5.2 Oatp1a3-v1/v2; 3.5.3 Oatp1a4; 3.5.4 Oatp1a5; 3.5.5 Oatp1a6; 3.5.6 Oatp1b2; 3.5.7 Oatp1c1; 3.5.8 Oatp2a1; 3.5.9 Oatp2b1; 3.5.10 Oatp3a1; 3.5.11 Oatp4a1; 3.5.12 Oatp4c1; 3.5.13 Oatp6b1/Oatp6c1; 3.5.14 PGT-23.5.15 TST-1 and TST-2This reference handbook is the first to provide a comprehensive overview, systematically characterizing all known transporters involved in drug elimination and resistance. Combining recent knowledge on all known classes of drug carriers, from microbes to man, it begins with a look at human and mammalian transporters. This is followed by microbial, fungal and parasitic transporters with special attention given to transport across those physiological barriers relevant for drug uptake, distribution and excretion.As a result, this key resource lays the foundations for understanding and investiMethods and principles in medicinal chemistry ;v. 44.Drug carriers (Pharmacy)DrugsPhysiological transportDrug resistanceDrug carriers (Pharmacy)DrugsPhysiological transport.Drug resistance.615.19Ecker Gerhard993852Chiba Peter1670750MiAaPQMiAaPQMiAaPQBOOK9910830216303321Transporters as drug carriers4032808UNINA