07556nam 22013693u 450 991083016460332120210114065954.01-280-59122-697866136210540-470-91509-90-470-91511-0(CKB)3400000000000281(EBL)698845(OCoLC)695561347(SSID)ssj0000550563(PQKBManifestationID)11341225(PQKBTitleCode)TC0000550563(PQKBWorkID)10509126(PQKB)10906858(MiAaPQ)EBC698845(PPN)237853906(EXLCZ)99340000000000028120131014d2012|||| u|| |engur|n|---|||||txtccrADMET for Medicinal Chemists[electronic resource] A Practical GuideHoboken Wiley20121 online resource (524 p.)Description based upon print version of record.0-470-48407-1 ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools4.5.7 Tools for Studying Drug ExcretionThis book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of different ways. This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME for medicinal chemists. In addition, the scientific principles and the tools utilized by ADME scientists in a discovery setting, as applDrug DesignDrug ToxicityDrugs - TestingDrugs --Testing --Juvenile literaturePharmaceutical Preparations - chemistryPharmacokineticsDrugsTestingJuvenile literatureMetabolic PhenomenaDrug DiscoveryPharmacological PhenomenaNatural Science DisciplinesKineticsChemicals and DrugsPoisoningBiochemical PhenomenaChemistry, PharmaceuticalSubstance-Related DisordersDisciplines and OccupationsInvestigative TechniquesPhysiological PhenomenaPhenomena and ProcessesChemical PhenomenaDiseasesPharmacologyAnalytical, Diagnostic and Therapeutic Techniques and EquipmentBiological Science DisciplinesDrug DesignPharmacokineticsChemistryDrug ToxicityPharmaceutical PreparationsHealth & Biological SciencesHILCCPharmacy, Therapeutics, & PharmacologyHILCCDrug Design.Drug Toxicity.Drugs - Testing.Drugs --Testing --Juvenile literature.Pharmaceutical Preparations - chemistry.Pharmacokinetics.DrugsTestingMetabolic PhenomenaDrug DiscoveryPharmacological PhenomenaNatural Science DisciplinesKineticsChemicals and DrugsPoisoningBiochemical PhenomenaChemistry, PharmaceuticalSubstance-Related DisordersDisciplines and OccupationsInvestigative TechniquesPhysiological PhenomenaPhenomena and ProcessesChemical PhenomenaDiseasesPharmacologyAnalytical, Diagnostic and Therapeutic Techniques and EquipmentBiological Science DisciplinesDrug DesignPharmacokineticsChemistryDrug ToxicityPharmaceutical PreparationsHealth & Biological SciencesPharmacy, Therapeutics, & Pharmacology615.19615/.19Tsaioun Katya1611274Kates Steven A240767AU-PeELAU-PeELAU-PeELBOOK9910830164603321ADMET for Medicinal Chemists3939450UNINA