03075oam 2200637zu 450 991083011340332120230607213148.01-280-65435-X0-470-84630-59786610654352(CKB)111056485557314(SSID)ssj0000148618(PQKBManifestationID)11144814(PQKBTitleCode)TC0000148618(PQKBWorkID)10224946(PQKB)10571592(MiAaPQ)EBC5247800(Au-PeEL)EBL5247800(CaONFJC)MIL65435(OCoLC)1027153479(EXLCZ)9911105648555731420160829d2002 uy engurcnu||||||||txtccrEnzyme systems that metabolise drugs and other xenobiotics1st ed.[Place of publication not identified]John Wiley & Sons20021 online resource (578 pages)Bibliographic Level Mode of Issuance: Monograph0-471-89466-4 0-470-85198-8 This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include:* enzyme function in the metabolism and bioactivation of xenobiotics* substrate specificity* tissue distribution* species distribution (to include laboratory animals and humans)* hormonal regulation* sex differences* modulation by prior exposure to other chemicals* age-dependent expression* pharmacogenetics and modulation by disease.Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties. The nature and scope of the book will also make it attractive to the research toxicologist and to postgraduate students studying toxicology, as well as to clinicians and pharmacists.Pharmaceutical PreparationsXenobioticsEnzymesChemicals and DrugsEnzymes and CoenzymesPharmacy, Therapeutics, & PharmacologyHILCCHealth & Biological SciencesHILCCPharmaceutical PreparationsXenobioticsEnzymesChemicals and DrugsEnzymes and CoenzymesPharmacy, Therapeutics, & PharmacologyHealth & Biological Sciences615.7Ioannides CostasPQKBBOOK9910830113403321Enzyme systems that metabolise drugs and other xenobiotics4077780UNINA