02971nam 22005774a 450 991083008500332120230721033134.01-281-93868-897866119386800-470-40910-X0-470-40905-3(CKB)1000000000551811(EBL)380501(OCoLC)437241459(SSID)ssj0000212701(PQKBManifestationID)11173616(PQKBTitleCode)TC0000212701(PQKBWorkID)10138878(PQKB)10551139(MiAaPQ)EBC380501(EXLCZ)99100000000055181120080703d2009 uy 0engur|n|---|||||txtccrNuclear receptors in drug metabolism[electronic resource] /edited by Wen XieHoboken, NJ John Wiley & Sonsc20091 online resource (362 p.)Description based upon print version of record.0-470-08679-3 Includes bibliographical references and index.Drug metabolism : significance and challenges -- Establishing orphan nuclear receptors PXR and CAR as xenobiotic receptors -- Nuclear receptor-mediated regulation of phase II conjugating enzymes -- Nuclear receptor-mediated regulation of drug transporters -- Structure and function of PXR and CAR -- Xenobiotic receptor cofactors and coregulators -- Animal models of xenobiotic nuclear receptors and their utility in drug development -- Nuclear receptors and drug-drug interactions of prescription drugs and herbal medicines -- Genetic variants of xenobiotic receptors and their implications in drug metabolism and pharmacogenetics -- Beyond PXR and CAR, regulation of xenobiotic metabolism by other nuclear receptors -- Emerging role of retinoid-related orphan receptor (ROR) and its cross talk with LXR (liver X receptor) in the regulation of drug-metabolizing enzymes.This book gives you an updated and expert overview of nuclear hormone receptors in drug metabolism and drug development and equips you with the interdisciplinary understanding of these receptors and how they can be regulated. Pharmaceutical researchers will find this extremely useful in developing drugs for cancer, heart disease, and diabetes treatment. This comprehensive resource collects scattered materials into one handy, informative volume.DrugsMetabolismNuclear receptors (Biochemistry)Genetic regulationDrugsMetabolism.Nuclear receptors (Biochemistry)Genetic regulation.615.19615/.7Xie Wen1967-1672776MiAaPQMiAaPQMiAaPQBOOK9910830085003321Nuclear receptors in drug metabolism4036335UNINA