03733nam 2200637 a 450 991083005430332120230421044522.01-282-13793-X97866121379380-470-51473-60-470-51474-4(CKB)1000000000376020(EBL)470700(OCoLC)649839031(SSID)ssj0000388235(PQKBManifestationID)11278786(PQKBTitleCode)TC0000388235(PQKBWorkID)10411377(PQKB)10102828(MiAaPQ)EBC470700(EXLCZ)99100000000037602019941110d1995 uy 0engur|n|---|||||txtccrSomatostatin and its receptors[electronic resource]Chichester ;New York Wiley19951 online resource (285 p.)Ciba Foundation symposium ;190Symposium on Somatostatin and its receptors, held at the Ciba Foundation, London 12-14 July 1994.Editors: Derek J. Chadwick (organizer) and Gail Cardew.0-471-95382-2 Includes bibliographical references and indexes.SOMATOSTATIN AND ITS RECEPTORS; Contents; Participants; Introduction; Regulation of somatostatin gene transcription by cAMP; Processing and intracellular targeting of prosomatostatin-derived peptides: the role of mammalian endoproteases; Anatomical localization and regulation of somatostatin gene expression in the basal ganglia and its clinical implications; Molecular biology of somatostatin receptors; Characterization of somatostatin receptor subtypes; Regulation of somatostatin receptor mRNA expression; Transient expression of somatostatin receptors in the brain during developmentExpression of sstrl and sstr2 in rat hypothalamus: correlation with receptor binding and distribution of growth hormone regulatory peptidesInteraction of somatostatin receptors with G proteins and cellular effector systems; Somatostatin modulates voltage- dependent Ca2+ channels in GH3 cells via a specific Go splice variant; A tyrosine phosphatase is associated with the somatostatin receptor1; Function and regulation of somatostatin receptor subtypes; Somatostatin receptors: clinical implications for endocrinology and oncologySomatostatin analogues and multiple receptors: possible physiological rolesFinal discussion; Summary; Appendix; Index of contributors; Subject indexThis book describes a diverse analysis of the five somatostatin receptors; somatostatin gene regulation; promatostatin processing; mechanisms of signal transduction; and the design and use of somatostatin analogues, including their possible clinical implications. The book will provide a comprehensive summary of the cellular and molecular biology of somatostatin and its recently isolated receptors. The book will review the design and use of specific somatostatin analogues both biochemically to characterize the specific functions of somatostatin and clinically in the treatment of various tumors.Ciba Foundation symposium ;190.SomatostatinCongressesSomatostatinReceptorsCongressesSomatostatinSomatostatinReceptors591.192456612.4/05612.405Chadwick Derek91632Cardew Gail857118MiAaPQMiAaPQMiAaPQBOOK9910830054303321Somatostatin and its receptors4087600UNINA