02549nam 2200637 a 450 991083002580332120210209181351.03-527-64211-01-282-78445-597866127844533-527-63011-23-527-63012-0(CKB)2560000000011809(EBL)540114(OCoLC)642662062(SSID)ssj0000413847(PQKBManifestationID)11313091(PQKBTitleCode)TC0000413847(PQKBWorkID)10385247(PQKB)11080743(MiAaPQ)EBC540114(MiAaPQ)EBC4042293(Au-PeEL)EBL4042293(CaPaEBR)ebr11114927(CaONFJC)MIL278445(OCoLC)958543997(PPN)198080980(EXLCZ)99256000000001180920100629d2010 uy 0engur|n|---|||||txtccrThe chemical biology of DNA damage[electronic resource] /edited by Nicholas E. Geacintov and Suse Broyde1st ed.Weinheim [Germany] Wiley20101 online resource (473 p.)Description based upon print version of record.3-527-32295-7 Includes bibliographical references and index.pt. 1. Chemistry and biology of DNA lesions -- pt. 2 New frontiers and challenges : understanding structure-function relationships and biological activity.Bringing the power of biochemical analysis to toxicology, this modern reference explains genotoxicity at the molecular level, showing the links between a DNA lesion and the resulting cellular or organismic response. Clearly divided into two main sections, Part 1 focuses on selected examples of important DNA lesions and their biological impact, while the second part covers current advances in assessing and predicting the genotoxic effects of chemicals, taking into account the biological responses mediated by the DNA repair, replication and transcription machineries.A ready reference for bioDNA damageDNA damage.572.8572.86 22Geacintov Nicholas E1653808Broyde Suse1653809MiAaPQMiAaPQMiAaPQBOOK9910830025803321The chemical biology of DNA damage4005291UNINA