03890nam 2200613Ia 450 991082993790332120230828231752.01-280-41117-197866104111770-470-03500-50-470-03499-8(CKB)1000000000357399(EBL)255723(SSID)ssj0000245851(PQKBManifestationID)11211418(PQKBTitleCode)TC0000245851(PQKBWorkID)10181220(PQKB)10013973(MiAaPQ)EBC255723(OCoLC)86221676(EXLCZ)99100000000035739920050331d2006 uy 0engur|n|---|||||txtccrSignalling pathways in acute oxygen sensing[electronic resource]Chichester, UK ;Hoboken, NJ John Wiley20061 online resource (302 p.)Novartis Foundation symposium ;272Description based upon print version of record.0-470-01457-1 Includes bibliographical references and indexes.Cover; Contents; Chair's introduction; Regulation of gene expression by HIF-1; DISCUSSION; Regulation of HIF: prolyl hydroxylases; DISCUSSION; General discussion I; Regulation of HIF: asparaginyl hydroxylation; DISCUSSION; Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells; DISCUSSION; The role of TASK-like K+ channels in oxygen sensing in the carotid body; DISCUSSION; Reactive oxygen species facilitate oxygen sensing; DISCUSSION; Oxygen sensing in neuroepithelial and adrenal chromaffin cells; DISCUSSIONHypoxic regulation of Ca2+ signalling in astrocytes and endothelial cellsDISCUSSION; General discussion II; Functional proteomics of BK potassium channels: defining the acute oxygen sensor; DISCUSSION; A central role for oxygen-sensitive K+ channels and mitochondria in the specialized oxygen-sensing system; DISCUSSION; Role for mitochondrial reactive oxygen species in hypoxic pulmonary vasoconstriction; DISCUSSION; Hypoxic pulmonary vasoconstriction-triggered by an increase in reactive oxygen species?; DISCUSSION; General discussion IIIThe role of twin pore domain and other K+ channels in hypoxicpulmonary vasoconstrictionDISCUSSION; AMP-activated protein kinase couples mitochondrial inhibition by hypoxia to cell-specific Ca2+ signalling mechanisms in oxygen-sensing cells; DISCUSSION; Role of capacitative Ca2+ entry but not Na+/Ca2+ exchange in hypoxic pulmonary vasoconstriction in rat intrapulmonary arteries; DISCUSSION; Final general discussion; Index of contributors; Subject indexOxygen sensing is a key physiological function of many tissues, but the identity of the sensor, the signalling pathways linking the sensor to the effector, and the endpoint effector mechanisms are all subjects of controversy. This book evaluates the various mediators that have been proposed, including the mitochondria, NAD(P)H oxidases, cytochrome p450 enzymes, and direct effects on enzymes and ion channels. There has been a resurgence of interest in the role of mitochondria, based partly on the ability of mitochondrial inhibitors to mimic hypoxia, but there is little consensus concerning mechNovartis Foundation symposium ;272.Oxygen in the bodyOxygenOxygen in the body.Oxygen.572.53573.1536Novartis Foundation.Symposium on Signalling Pathways in Acute Oxygen SensingMiAaPQMiAaPQMiAaPQBOOK9910829937903321Signalling pathways in acute oxygen sensing3976386UNINA03078nam0 22006373i 450 SBL007534120251003044349.08806085654IT6613472 20190213d1966 ||||0itac50 baitafreitz01i xxxe z01nz01ncRDAcarrierˆLa ‰nascita dell'Europasecoli 5.-14.Roberto S. LopezEd. italiana riveduta e ampliataTorinoEinaudi©1966XXII, 458 p., [16] carte di tav.ill.22 cm.Biblioteca di cultura storica90001CFI00146832001 Biblioteca di cultura storica90Naissance de l'EuropeMOL0094674CFIV04049337917EuropaStoriaSec. 5.-14.FIRCFIC007161IEuropaStoriaSaggiFIRSBLC055496IEUROPAStoriaSec. 4.-14.FIRNAPC039436I940STORIA GENERALE DELL'EUROPA20940.1STORIA GENERALE DELL'EUROPA. DALLE ORIGINI AL 145312940.1STORIA D'EUROPA. Storia antica fino al 145314940.1STORIA. EUROPA. MEDIOEVO16940.119940.1Storia generale d'Europa. Fino al 145320940.1STORIA GENERALE DELL'EUROPA FINO AL 145321940.1STORIA GENERALE DELL'EUROPA FINO AL 145323T.1Storia della scienzaACQLopez, Roberto S.CFIV040493070413735Lopez, Roberto SabatinoCFIV224288Lopez, Roberto S.Lopez, Robert S.MILV135809Lopez, Roberto S.Lopez, RobertoMILV135810Lopez, Roberto S.ITIT-00000020190213IT-BN0095 IT-NA0622 IT-SA0060 IT-SA0037 IT-AV0003 IT-NA0079 IT-NA0070 IT-NA0120 IT-NA0666 IT-NA0230 IT-AV0045 IT-NA0742 IT-NA0097 NAP MVH ARTE E STORIANAP GVF. MODERNO$NAP GVF.MARTANO $NAP 21CENTRALE $NAP SPRUGGIERO Fondo RuggieroNAP NZDEL MON. $NAP 42S. MODERNA$NAP 01POZZO LIB.Vi sono collocati fondi di economia, periodici di ingegneria e scienze, periodici di economia e statistica e altri fondi comprendenti documenti di economia pervenuti in dono. NAP 27SALA $NAP ARP. CICCONEDONAZIONENAP BNS.C. $SBL0075341Biblioteca Centralizzata di Ateneo1 v. 01POZZO LIB.ECON MON 6121 0101 0700182325E VMA 1 v. (Precedente collocazione 18 EC 232)B 2022060920220609 01 21 27 42 AR BN BU CR GV IR MV NZ SPNaissance de l'Europe37917UNISANNIO