01840nam 2200421 450 991015484130332120230810001454.01-63472-228-0(CKB)3710000000972086(MiAaPQ)EBC5155348(EXLCZ)99371000000097208620180507d2017 ay 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierBridges /by Virginia Loh-HaganAnn Arbor :Cherry Lake Publishing,[2017]1 online resource (24 pages) illustrations21st century junior library. Extraordinary engineering1-63472-162-4 Includes bibliographical references and index.What are bridges? -- How are short and long bridges supported? -- How do arch bridges work? -- How do bridges hang in the air? -- Try this!"The 21st Century Junior Library Extraordinary Engineering series explains how important feats of engineering are accomplished. Bridges examines the engineering concepts that make these critical structures possible. Sidebars encourage readers to engage in the material by asking deeper questions or conducting individual research. An activity, full color photos, a glossary, and a listing of additional resources all enhance the learning experience"--Provided by publisher.BridgesJuvenile literatureBridgesDesign and constructionJuvenile literatureBridgesBridgesDesign and construction624.2Loh-Hagan Virginia1225467MiAaPQMiAaPQMiAaPQBOOK9910154841303321Bridges2888777UNINA04249nam 2200613Ia 450 991082980600332120220326012936.01-68367-095-71-283-65648-51-55581-717-3(CKB)2670000000261697(EBL)1039537(OCoLC)811962835(SSID)ssj0000720149(PQKBManifestationID)11467334(PQKBTitleCode)TC0000720149(PQKBWorkID)10668468(PQKB)11297948(MiAaPQ)EBC1039537(PPN)172571391(EXLCZ)99267000000026169720110616d2012 uy 0engur|n|---|||||txtccrCandida and candidiasis[electronic resource] /edited by Richard A. Calderone, Cornelius J. Clancy2nd ed.Washington, DC ASM Pressc20121 online resource (544 p.)Description based upon print version of record.1-55581-539-1 Includes bibliographical references and index.Cover; Contents; Contributors; Preface; 1 Candida: What Should Clinicians and Scientists Be Talking About?; SECTION I: THE ORGANISMS, THEIR GENOMICS, AND VARIABILITY; 2 An Introduction to the Medically Important Candida Species; 3 Comparative Genomics of Candida Species; 4 The Genetic Code of the Candida CTG Clade; 5 Genome Instability and DNA Repair; 6 Switching and Mating; 7 Detection and Clinical Significance of Variability among Candida Isolates; 8 Cell Cycle and Growth Control in Candida Species; SECTION II: HOST-PATHOGEN INTERACTIONS (THE HOST); 9 Immunology of Invasive Candidiasis10 Mucosal Immunity to Candida albicans11 Innate Immunity to Candida Infections; 12 Vaccines and Passive Immunity against Candidiasis; 13 Salivary Histatins: Structure, Function, and Mechanisms of Antifungal Activity; SECTION III: HOST-PATHOGEN INTERACTIONS THE PATHOGEN); 14 The Cell Wall: Glycoproteins, Remodeling, and Regulation; 15 Stress Responses in Candida; 16 Adhesins in Opportunistic Fungal Pathogens; 17 Encounters with Mammalian Cells: Survival Strategies of Candida Species; 18 Gene Expression during the Distinct Stages of Candidiasis; 19 Biofilm Formation in Candida albicans20 Candida spp. in Microbial Populations and Communities: Molecular Interactions and Biological Importance21 Back to the Future: Candida Mitochondria and Energetics; SECTION IV: ANTIFUNGAL DRUGS, DRUG RESISTANCE, AND DISCOVERY; 22 Antifungals: Drug Class, Mechanisms of Action, Pharmacokinetics/Pharmacodynamics, Drug-Drug Interactions, Toxicity, and Clinical Use; 23 The Impact of Antifungal Drug Resistance in the Clinic; 24 Insights in Antifungal Drug Discovery; 25 Multidrug Resistance Transcriptional Regulatory Networks in CandidaSECTION V: CANDIDIASIS, EVOLVING DIAGNOSTICS, AND TREATMENT PARADIGMS26 Mucosal Candidiasis; 27 Systemic Candidiasis: Candidemia and Deep-Organ Infections; 28 New Developments in Diagnostics and Management of Invasive Candidiasis; 29 The Epidemiology of Invasive Candidiasis; SECTION VI: COOL TOOLS FOR RESEARCH; 30 Cool Tools 1: Development and Application of a Candida albicans Two-Hybrid System; 31 Cool Tools 2: Development of a Candida albicans Cell Surface Protein Microarray; 32 Cool Tools 3: Large-Scale Genetic Interaction Screening in Candida albicans33 Cool Tools 4: Imaging Candida Infections in the Live Host34 Cool Tools 5: The Candida albicans ORFeome Project; Index; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; X; Y; ZThe underlying mechanisms of Candida and candidiasis and promising new directions in drug discovery and treatment.CandidiasisCandidaCandidiasis.Candida.616.969Calderone Richard A.1942-1717099Clancy Cornelius J1717100MiAaPQMiAaPQMiAaPQBOOK9910829806003321Candida and candidiasis4112950UNINA