03409nam 22007094a 450 991082917540332120200520144314.01-107-13017-41-280-16041-197866101604190-511-06321-00-511-11922-41-139-14694-70-511-05688-50-511-32267-40-511-54177-50-511-07167-1(CKB)1000000000018014(EBL)217773(OCoLC)57417979(SSID)ssj0000140418(PQKBManifestationID)11149587(PQKBTitleCode)TC0000140418(PQKBWorkID)10029822(PQKB)11778684(UkCbUP)CR9780511541773(Au-PeEL)EBL217773(CaPaEBR)ebr10069815(CaONFJC)MIL16041(MiAaPQ)EBC217773(PPN)261307746(EXLCZ)99100000000001801420011105d2002 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierDNA microarrays and gene expression /Pierre Baldi and G. Wesley Hatfield1st ed.Cambridge, UK ;New York, NY Cambridge University Press20021 online resource (xvi, 213 pages) digital, PDF file(s)Title from publisher's bibliographic system (viewed on 05 Oct 2015).0-521-17635-2 0-521-80022-6 Includes bibliographical references and index.Cover; Half-title; Title; Copyright; Contents; Preface; 1 A brief history of genomics; 2 DNA array formats; 3 DNA array readout methods; 4 Gene expression profiling experiments: Problems, pitfalls, and solutions; 5 Statistical analysis of array data: Inferring changes; 6 Statistical analysis of array data: Dimensionality reduction,clustering,and regulatory regions; 7 The design, analysis,and interpretation of gene expression profiling experiments; 8 Systems biology; Appendix A; Appendix B; Appendix C; Appendix D; IndexMassive data acquisition technologies, such as genome sequencing, high-throughput drug screening, and DNA arrays are in the process of revolutionizing biology and medicine. Using the mRNA of a given cell, at a given time, under a given set of conditions, DNA microarrays can provide a snapshot of the level of expression of all the genes in the cell. Such snapshots can be used to study fundamental biological phenomena such as development or evolution, to determine the function of new genes, to infer the role individual genes or groups of genes may play in diseases, and to monitor the effect of drugs and other compounds on gene expression. Originally published in 2002, this inter-disciplinary introduction to DNA arrays will be of value to anyone with an a interest in this powerful technology.DNA microarraysGene expressionDNA microarrays.Gene expression.572.8/65Baldi Pierre282482Hatfield G. Wesley1940-1763562MiAaPQMiAaPQMiAaPQBOOK9910829175403321DNA microarrays and gene expression4204076UNINA