03312nam 2200673Ia 450 991082871390332120240417004641.00-309-14231-81-282-27265-997866122726530-309-13125-1(CKB)1000000000789198(OCoLC)427878159(CaPaEBR)ebrary10327027(SSID)ssj0000096382(PQKBManifestationID)11121580(PQKBTitleCode)TC0000096382(PQKBWorkID)10076939(PQKB)10857566(MiAaPQ)EBC3378514(Au-PeEL)EBL3378514(CaPaEBR)ebr10327027(CaONFJC)MIL227265(OCoLC)923280588(EXLCZ)99100000000078919820090819d2009 uy 0engurcn|||||||||txtccrAccelerating the development of biomarkers for drug safety[electronic resource] workshop summary /Steve Olson, Sally Robinson and Robert Giffin, rapporteurs ; Forum on Drug Discovery, Development, and Translation, Board on Health Sciences Policy, Institute of Medicine of the National Academies1st ed.Washington, D.C. National Academies Pressc20091 online resource (99 p.) Bibliographic Level Mode of Issuance: Monograph0-309-13124-3 Includes bibliographical references (p. 55-57).Overview Of key issues -- Cardiac safety biomarkers -- Assessing and predicting kidney safety -- Biomarkers of acute idiosyncratic hepatocellular injury in clinical trials -- Future considerations."Biomarkers can be defined as indicators of any biologic state, and they are central to the future of medicine. As the cost of developing drugs has risen in recent years, reducing the number of new drugs approved for use, biomarker development may be a way to cut costs, enhance safety, and provide a more focused and rational pathway to drug development. On October 24, 2008, the IOM's Forum on Drug Discovery, Development, and Translation held 'Assessing and Accelerating Development of Biomarkers for Drug Safety,' a one-day workshop, summarized in this volume, on the value of biomarkers in helping to determine drug safety during development."--Publisher's website.Biochemical markersCongressesDrugsSafety measuresCongressesDrugsTestingCongressesBiochemical markersDrugsSafety measuresDrugsTesting616.075Giffin Robert B1653478Olson Steve1956-488724Robinson Sally620917National Research Council (U.S.).Planning Committee for Assessing and Accelerating the Development of Biomarkers for Drug Safety : a Workshop.Assessing and Accelerating the Development of Biomarkers for Drug Safety. Workshop(2008 :Washington, D.C.)MiAaPQMiAaPQMiAaPQBOOK9910828713903321Accelerating the development of biomarkers for drug safety4036727UNINA