03013nam 2200589Ia 450 991082841110332120200520144314.01-280-22163-197866102216390-309-55513-20-585-14460-5(CKB)111004366657404(OCoLC)427404809(CaPaEBR)ebrary10062946(SSID)ssj0000127240(PQKBManifestationID)11139730(PQKBTitleCode)TC0000127240(PQKBWorkID)10051710(PQKB)10480426(MiAaPQ)EBC3377011(Au-PeEL)EBL3377011(CaPaEBR)ebr10062946(OCoLC)923267638(EXLCZ)9911100436665740419870928d1988 uy 0engurcn|||||||||txtrdacontentcrdamediacrrdacarrierComplex mixtures methods for in vivo toxicity testing /Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council1st ed.Washington, D.C. National Academy Press19881 online resource (xi, 227 pages) illustrationsBibliographic Level Mode of Issuance: Monograph0-309-03778-6 Includes bibliographies and index.1 Front Matter; 2 Executive Summary; 3 1. Introduction; 4 2. Concepts for Analyzing Human Exposure to Complex Chemical Mixtures; 5 3. Testing Strategies and Methods; 6 4. Sampling and Chemical Characterization; 7 5. Interpretation and Modeling of Toxicity-Test Results; 8 Appendix A: Origins of Complex Mixtures; 9 Appendix B: Case Studies Establishing Active Agents and/or Interactions in Complex Mixtures; 10 Appendix C: Case Studies on Strategies for Testing the Toxicity of Complex Mixtures; 11 Appendix D: Predicting the Joint Risk of a Misture in Terms of the Component Risks; 12 Appendix E: Cancer Models; 13 Appendix F: Developmental Toxicology; 14 Appendix G: Empirical Modeling of the Toxicity of Mixtures; 15 IndexAddresses the problem of identifying and classifying complex mixtures, investigating the effect of exposure, and the research problems inherent in testing their toxicity to human beings. A series of case studies is presented, including one that examines the cofactors of alcohol consumption and cigarette smoke.Toxicity testingEvaluationToxicology, ExperimentalToxicity testingEvaluation.Toxicology, Experimental.615.9/07National Research Council (U.S.).Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures.MiAaPQMiAaPQMiAaPQBOOK9910828411103321Complex mixtures4033864UNINA