04994nam 2200781 a 450 991082825460332120240516065100.09786613694416978128078402612807840249780470720769047072076X97804707184690470718463(CKB)1000000000688149(EBL)703915(OCoLC)797918499(SSID)ssj0000715494(PQKBManifestationID)11400817(PQKBTitleCode)TC0000715494(PQKBWorkID)10703767(PQKB)10330227(MiAaPQ)EBC703915(Au-PeEL)EBL703915(CaPaEBR)ebr10575609(CaONFJC)MIL369441(Perlego)2753489(EXLCZ)99100000000068814919830426d1983 uy 0engurcn|||||||||txtccrBrush border membranes1st ed.London Pitmanc19831 online resource (352 p.)Ciba Foundation symposium ;v. 95Editors: Ruth Porter (Organizer) and Geralyn M. Collins.Proceedings of Symposium on: Brush border membranes held at the Ciba Foundation, London, 8-10 June 1982.9780470664131 0470664134 9780272796597 027279659X Includes bibliographical references and indexes.Brush border membranes; Contents; Chairman's introduction; Introductory remarks on the brush border; Microvillar endopeptidase, an enzyme with special topological features and a wide distribution; Discussion; Aminopeptidases and proteolipids of intestinal brush border; Discussion; Structure of microvillar enzymes in different phases of their life cycles; Discussion; Specific labelling of the hydrophobic domain of rat renal y-glutamyl transferase; Discussion; Biosynthesis and assembly of the largest and major intrinsic polypeptide of the small intestinal brush borders; DiscussionUse of monoclonal antibodies in the study of intestinal structure and function Discussion; Biosynthesis and transport of plasma membrane glyco- proteins in the rat intestinal epithelial cell: studies with sucrase- isomaltase; Discussion; GENERAL DISCUSSION I Biosynthesis and assembly of brush border proteins: (i) some co-translational models for protein insertion into membranes; molecular sizes of brush border enzymes during assembly; Distribution of enteropeptidase and aminopeptidase to non-brush border sites; General functions of the enterocyteMolecular architecture of the microvillus cytoskeleton Discussion; Structure of human placental microvilli; Discussion; Regulation of cytoskeletal structure and contractility in the brush border; Discussion; Characterization of membrane glycoproteins involved in attachment of microfilaments to the microvillar membrane; Discussion; Structural and functional relationship between the membrane and the cytoskeleton in brush border microvilli; Discussion; GENERAL DISCUSSION II A pathological condition due to congenital disorganization of the brush borderConformational changes in the a-subunit, and cation transport by Na+, K+-ATPase Discussion; Properties of immunoglobulin G-Fc receptors from neonatal rat intestinal brush borders; Immunoglobulin G receptors of intestinal brush borders from neonatal rats; Discussion after the preceding two papers; Cotransport systems in the brush border membrane of the human placenta; Discussion; GENERAL DISCUSSION III Cytoskeleton and membrane-cytoskeleton interactions; The importance of structure for understanding the biosynthetic process; Future advances in study of brush border cytoskeletonPhoto-affinity labeling to identify components of the neutral amino acid carrier in the intestinal microvillar membrane Chairman's closing remarks; Index to contributors; Subject indexThe Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world. Ciba Foundation symposium ;v. 95.Cell membranesCongressesCell physiologyCongressesCell membranesCell physiology611.0181611/.0181Porter Ruth64811Collins Geralyn M868426MiAaPQMiAaPQMiAaPQBOOK9910828254603321Brush border membranes1991734UNINA