04593nam 2200637Ia 450 991082800130332120200520144314.01-282-49198-997866124919861-4443-1965-51-4443-1966-3(CKB)2670000000013698(EBL)496049(OCoLC)632158152(SSID)ssj0000358046(PQKBManifestationID)11254517(PQKBTitleCode)TC0000358046(PQKBWorkID)10359187(PQKB)10669752(MiAaPQ)EBC496049(Au-PeEL)EBL496049(CaPaEBR)ebr10373039(CaONFJC)MIL249198(PPN)198234732(EXLCZ)99267000000001369820091104d2010 uy 0engur|n|---|||||txtccrThe colors of mice[electronic resource] a model genetic network /M. Lynn Lamoreux ... [et al.]Chichester, West Sussex ;Hoboken, NJ Wiley-Blackwell20101 online resource (311 p.)Description based upon print version of record.1-4051-7954-6 Includes bibliographical references and index.The Colors of Mice; Contents; Preface; Acknowledgments; Statement regarding the use of pictures; Statement regarding nomenclature; Part I Introduction to the Pigmentary System; 1 Introduction to the Pigmentary System; 1.1 Introduction; 1.2 Colors of vertebrate animals; 1.3 Other pigment cells; 1.4 The epidermal melanin unit; 1.5 Mammalian hair; 1.6 Melanosome biogenesis and translocation; 1.7 Melanin; 1.8 Hair growth; 1.9 Hair growth cycles; 1.10 Embryonic development of the pigment cell lineage; 1.11 Pigment cells in culture; 1.12 Conclusion; Appendix: color loci of the mousePart II The Pigmentary Loci2 Introduction to Mutant Pigmentary Genes; 2.1 Defects of normal melanocyte development: white spotting and graying with age; 2.2 Defects in normal melanosome development: albinism; 2.3 Transport of melanosomes to other cells: the 'dilute' phenotype; 2.4 Pigment-type switching: from eumelanogenesis to pheomelanogenesis; 3 White Spotting and Progressive Graying; 3.1 Definitions and general background; 3.2 Pigment-cell development: developmental biology; 3.3 Cellular signaling pathways for melanocytes; 3.4 Pigment phenotypes and the classical white-spotting genes3.5 The head, heart, ears, and eyes4 'Albinism' and the Failure of Normal Melanosome Maturation; 4.1 Background; 4.2 The melanosomal matrix; 4.3 The enzymes that catalyze melanogenesis; 4.4 Membrane proteins that regulate the internal milieu of the melanosome; 4.5 Protein processing and routing to the maturing melanosome; 4.6 Melanosome transport; 5 Pigment-Type Switching; 5.1 Introduction; 5.2 Yellow phenotypes; 5.3 Melanin pigment; 5.4 Melanogenesis and the eumelanin/pheomelanin switch mechanism; 5.5 Signaling the switch mechanism at the cellular level; 5.6 Yellow genesPart III Technology and Resources6 Novel Mouse Pigmentary Mutants Generated by Genetic Manipulation; 6.1 Introduction; 6.2 Mouse transgenesis: generation of genetically engineered mice; 6.3 Coat-color transgenic mice; 6.4 The coat-color mutants generated by gene targeting; 6.5 Influence of the genetic background; 6.6 Conclusions; 7 Other Species and Other Resources; 7.1 Introduction; 7.2 Resources; 7.3 Other species; References; IndexServing the needs of pigment cell biologists, cellular physiologists, developmental geneticists, researchers interested in melanoma and more, this new book showcases a blend of new technologies and new insights in the field of pigmantary genetics of mice, with comparative information on other animals. Graduate students can learn here the terminology and scope of the field, and animal fanciers can discover the genetics behind common color variants of mammals. The book is hailed for being written by four of the premier scientists in the field. These authors aim to present the molecular /cellularMiceColorGeneticsMice as laboratory animalsMiceColorGenetics.Mice as laboratory animals.572.591935599.35/3138Lamoreux M. Lynn1656061MiAaPQMiAaPQMiAaPQBOOK9910828001303321The colors of mice4008712UNINA