03756nam 2200601 a 450 991082797900332120240417005413.00-309-18700-11-282-97605-297866129760560-309-16325-0(CKB)2550000000032049(OCoLC)707927323(CaPaEBR)ebrary10443278(SSID)ssj0000540006(PQKBManifestationID)11385680(PQKBTitleCode)TC0000540006(PQKBWorkID)10585251(PQKB)11286098(MiAaPQ)EBC3378736(Au-PeEL)EBL3378736(CaPaEBR)ebr10443278(CaONFJC)MIL297605(OCoLC)923283031(EXLCZ)99255000000003204920110215d2011 uy 0engurcn|||||||||txtccrPerspectives on biomarker and surrogate endpoint evaluation discussion forum summary /Alison Mack, Erin Balogh, and Christine M. Micheel ; Committee on Qualification of Biomarkers and Surrogate Endpoints in Chronic Disease1st ed.Washington, D.C. National Academies Press20111 online resource (139 p.) Bibliographic Level Mode of Issuance: Monograph0-309-16324-2 Includes bibliographical references (p. 99-102).Introduction -- Committee findings and recommendations -- FDA perspectives -- National institutes of health perspectives -- Industry perspectives -- Public health, consumer, and consulting organization perspectives -- Presentation by Thomas Fleming: biomarkers and surrogate endpoints in chronic disease -- Key themes, challenges, and opportunities -- Importance of the biomarker discussion forum.In 2010 the Institute of Medicine (IOM) recommended a framework for the evaluation of biomarkers in the chronic disease setting. Published in the book Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease, the framework is intended to bring consistency and transparency to the previously disparate process of biomarker evaluation. Following the book's release, the IOM convened a 2-day discussion forum in Washington, DC, in order to provide an opportunity for stakeholders to learn about, react to, and discuss the book. Presentations reviewed the authoring committee's work process, recommendations, and provided perspectives on the book from the point of view of participants. Thomas Fleming, professor of biostatistics and statistics at the University of Washington, gave a keynote presentation on the critical issues in the validation of surrogate endpoints, a specific use of a biomarker. The present volume recounts the discussion forum proceedings, focusing in turn on each represented sector. A summary of Dr. Fleming's presentation then sets the committee's recommendations within the context of biomarker utilization. Lastly, this summary examines the main themes raised by stakeholders, and the challenges and opportunities presented to stakeholders by the book's recommendations.--Source other than Library of Congress.Biochemical markersBiochemical markers.Mack Alison1085987Balogh Erin1089066Micheel Christine1613229Institute of Medicine (U.S.).Committee on Qualification of Biomarkers and Surrogate Endpoints in Chronic Disease.MiAaPQMiAaPQMiAaPQBOOK9910827979003321Perspectives on biomarker and surrogate endpoint evaluation4072913UNINA